DegronMD

Uniprot ID: O94823

Source protein: Phospholipid-transporting ATPase VB

Source gene: ATP10B

Class: DEG_SPOP_SBC_1

Location: 535:539

E3 ligase: SPOP

DEGRON score: 0.6502

ASA_SCORE: 55.9

COIL: 0.5754

CONS_SCORE: 0.4906

DSS_SCORE: 0.5961

HELIX: 0.1302

FCONS_SCORE: 1.0131

RIG_SCORE: 0.6694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R527C	TCGA-AJ-A3EL	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R527C	TCGA-AX-A0J1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R527C	DO41542	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R527C	DO41199	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R527C	SIDM01588	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R527C	ACH-000993	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1111
p.S538R	TCGA-AX-A1CE	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.7427
p.S538R	DO42280	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.7427
p.S538R	ACH-001143	Lymphoma	CCLE	AFSSS	DEG_SPOP_SBC_1	0.7427
p.S530P	TCGA-C8-A12X	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1944
p.S530P	DO3751	BRCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.V534A	TCGA-DD-AACX	LIHC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.V534A	DO52215	LIHC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.A535V	TCGA-WS-AB45	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.5825
p.A535V	DO51734	COAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.5825
p.I540T	SIDM00674	Non-Cancerous	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.I540T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.I540T	SIDM00844	Burkitt's Lymphoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.I540T	SIDM01664	Prostate Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.I540T	SIDM01525	Acute Myeloid Leukemia	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S538I	ACH-000790	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons