DegronMD

Uniprot ID: P08235

Source protein: Mineralocorticoid receptor

Source gene: NR3C2

Class: DEG_SPOP_SBC_1

Location: 405:409

E3 ligase: SPOP

DEGRON score: 0.9658

ASA_SCORE: 58

COIL: 0.7034

CONS_SCORE: 0.6469

DSS_SCORE: 0.4396

HELIX: 0.2192

FCONS_SCORE: 1.0737

RIG_SCORE: 0.7214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C410F	TCGA-A5-A0G1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.C410F	DO42472	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.G404R	TCGA-A5-A0G1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.G404R	DO42472	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S407T	TCGA-A8-A07L	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.6005
p.S407T	DO2377	BRCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.6005
p.S419L	TCGA-BS-A0UV	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S419L	TCGA-FW-A3R5	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S419L	DO220891	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S419L	DO37406	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S419L	DO42793	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S407R	TCGA-E6-A1LX	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.7427
p.S407R	DO41020	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.7427
p.K399Q	TCGA-EO-A22X	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2778
p.K399Q	DO43907	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.L411V	TCGA-P3-A5QF	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2778
p.L411V	DO44439	HNSC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.Y397C	TCGA-XK-AAIW	PRAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.Y397C	DO51407	PRAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.G412R	SIDM01169	Ovarian Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.25
p.G412R	ACH-000885	Ovarian Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.25
p.G412R	TOV-21G	ovary	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons