DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SPOP_SBC_1

Location: 842:846

E3 ligase: SPOP

DEGRON score: 0.9053

ASA_SCORE: 72.16

COIL: 0.731

CONS_SCORE: 0.426

DSS_SCORE: 0.4265

HELIX: 0.1834

FCONS_SCORE: 1.0155

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M836I	TCGA-A5-A0G2	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1667
p.G840V	TCGA-AR-A24Q	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2778
p.A837T	TCGA-E6-A1LX	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1944
p.E847K	TCGA-FW-A3R5	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.H845N	DO229022	LICA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.7423
p.A832V	DO46657	PAAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S852I	DO36881	READ	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1667
p.A835V	SIDM02041	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.I856T	SIDM01960	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.L848P	SIDM00333	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.L848P	ACH-000988	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.2778
p.L848P	MFE-319	endometrium	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.P853H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P853H	ACH-000900	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P853H	NCI-H23	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.A837E	SIDM01587	Bladder Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.A837E	ACH-000753	Bladder Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1944
p.G840R	ACH-000488	Esophageal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S833F	SW684	soft_tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0833
p.P842S	NCI-H2009	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.6752
p.A832S	NCI-H740	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.T837A	CAL-51	breast	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons