DegronMD - Q8N7K0(ZNF433)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S294F	TCGA-A5-A0G2	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7982
p.A290T	TCGA-A5-A0GP	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7139
p.R302I	TCGA-AN-A046	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.R302I	TCGA-D1-A17Q	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.R302I	TCGA-EY-A1GI	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.Y59H	TCGA-BR-8487	STAD	TCGA	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.F291L	TCGA-CN-6011	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.587
p.N61Y	TCGA-E6-A1LX	UCEC	TCGA	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.E70K	DO6320	CESC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7022
p.E70K	DO234400	ESAD	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7022
p.E70K	DO222529	ESCA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7022
p.E70K	DO43907	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7022
p.E70K	DO41488	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7022
p.A80D	DO229036	LICA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.0556
p.G65R	DO222837	MELA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7568
p.K300E	DO38404	STAD	ICGC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1667
p.G78D	DO41235	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1111
p.R291C	DO43891	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.8301
p.R295I	DO42793	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.3056
p.I55M	SIDM01020	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00570	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00584	Osteosarcoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00291	Melanoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00544	Neuroblastoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01145	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00592	Oral Cavity Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01181	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01196	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00487	Colorectal Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00292	Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00024	Non-Cancerous	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01653	Non-Cancerous	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00207	Glioblastoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00807	Bladder Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00018	Acute Myeloid Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00988	Kidney Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00616	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00241	Breast Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00543	Melanoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00996	Thyroid Gland Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00381	Cervical Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM00531	Pancreatic Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01439	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01372	Pancreatic Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01335	Kidney Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01470	Acute Myeloid Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01393	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01377	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01573	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01347	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01658	Unknown	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01473	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.I55M	SIDM01343	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1389
p.R72I	SIDM01169	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.2778
p.R72I	ACH-000885	Ovarian Cancer	CCLE	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.2778
p.R72I	TOV-21G	ovary	COSMIC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.2778
p.S292I	SIDM00136	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7341
p.S292I	ACH-000552	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7341
p.S292I	HT-29	large intestine	COSMIC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7341
p.Y59C	SIDM01045	Endometrial Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.Y59C	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.Y59C	EN	endometrium	COSMIC	LRRNLRIVG	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.K301N	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF433

UniProt ID: Q8N7K0

Entrez ID: 163059

Protein name: Zinc finger protein 433

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF433 in