DegronMD

Uniprot ID: Q8N7K0

Source protein: Zinc finger protein 433

Source gene: ZNF433

Class: DEG_SPOP_SBC_1

Location: 290:294

E3 ligase: SPOP

DEGRON score: 0.5748

ASA_SCORE: 51.46

COIL: 0.6634

CONS_SCORE: 0.5273

DSS_SCORE: 0.241

HELIX: 0.0726

FCONS_SCORE: 0.8893

RIG_SCORE: 0.6692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S294F	TCGA-A5-A0G2	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.7982
p.A290T	TCGA-A5-A0GP	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.7139
p.R302I	TCGA-AN-A046	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R302I	TCGA-D1-A17Q	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R302I	TCGA-EY-A1GI	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.F291L	TCGA-CN-6011	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.587
p.K300E	DO38404	STAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1667
p.R291C	DO43891	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.8301
p.R295I	DO42793	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S292I	SIDM00136	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.7341
p.S292I	ACH-000552	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.7341
p.S292I	HT-29	large_intestine	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.7341
p.K301N	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons