DegronMD - A8MVW0(FAM171A2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L408V	TCGA-2W-A8YY	CESC	TCGA	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.25
p.L408V	DO223732	CESC	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.25
p.S400L	TCGA-IR-A3LK	CESC	TCGA	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation blocking phosphorylation signal	0.75
p.S400L	DO44299	CESC	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation blocking phosphorylation signal	0.75
p.A409V	TCGA-JY-A93D	ESCA	TCGA	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2222
p.R412Q	DO233652	GACA	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.1389
p.D407E	DO233901	GACA	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2778
p.H399N	DO228253	MALY	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2778
p.F415L	DO229224	THCA	ICGC	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.0556
p.L398F	ACH-000628	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.25
p.R406Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons