DegronMD

Uniprot ID: A8MVW0

Source protein: Protein FAM171A2

Source gene: FAM171A2

Class: DEG_SPOP_SBC_1

Location: 401:405

E3 ligase: SPOP

DEGRON score: 0.9201

ASA_SCORE: 61.96

COIL: 0.654

CONS_SCORE: 0.4738

DSS_SCORE: 0.6834

HELIX: 0.29

FCONS_SCORE: 1.0251

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L408V	TCGA-2W-A8YY	CESC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.25
p.L408V	DO223732	CESC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.S400L	TCGA-IR-A3LK	CESC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.75
p.S400L	DO44299	CESC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.75
p.A409V	TCGA-JY-A93D	ESCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R412Q	DO233652	GACA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.D407E	DO233901	GACA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.H399N	DO228253	MALY	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.F415L	DO229224	THCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.L398F	ACH-000628	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.25
p.R406Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons