DegronMD - Q9Y2K5(R3HDM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P613S	TCGA-55-7576	LUAD	TCGA	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.2222
p.P613S	DO24431	LUAD	ICGC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.2222
p.Q596H	TCGA-69-7979	LUAD	TCGA	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.1667
p.S329N	TCGA-DK-A2I4	BLCA	TCGA	PWSST	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7069
p.E24K	TCGA-LN-A49L	ESCA	TCGA	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.1111
p.S322Y	TCGA-O2-A52S	LUSC	TCGA	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.R338W	TCGA-Z2-A8RT	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.K34N	DO1146	BRCA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation altering degron motif	0.5806
p.E285K	DO234411	ESAD	ICGC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.3056
p.M23I	DO233189	GACA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.0833
p.L467R	DO233081	GACA	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.7316
p.L32M	DO228985	LICA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation altering degron motif	0.711
p.Q283K	DO229029	LICA	ICGC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.25
p.D317E	DO229035	LICA	ICGC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.N28K	DO229035	LICA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation substituting flanking lysine	0.3333
p.G599D	DO23548	LIRI	ICGC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.25
p.Q323H	DO23874	LUAD	ICGC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R317S	DO45322	LUAD	ICGC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.S49Y	DO219221	LUSC	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.0556
p.M462T	DO38599	STAD	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.7423
p.Y459H	DO42280	UCEC	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.25
p.R317M	DO41999	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.P278H	DO42568	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1111
p.E288D	DO41199	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.6758
p.P462L	SIDM00318	Kidney Carcinoma	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.7582
p.P462L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.7582
p.S288Y	SIDM00193	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.712
p.S288Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.712
p.S288Y	SNU-81	large intestine	COSMIC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.712
p.E42D	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.25
p.E42D	ACH-000841	Lung Cancer	CCLE	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.25
p.E42D	NCI-H2087	lung	COSMIC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.25
p.F476V	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.1389
p.P463S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.6752
p.P463S	NCI-H1755	lung	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.6752
p.M340T	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.M340T	ACH-000220	Lymphoma	CCLE	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.G595S	ACH-000220	Lymphoma	CCLE	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.1389
p.F463L	ACH-000368	Brain Cancer	CCLE	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.587
p.G594R	ACH-000425	Skin Cancer	CCLE	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.1111
p.G594R	UACC-62	skin	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.1111
p.M593V	HCC-44	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.0833
p.G608R	UACC-62	skin	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation altering degron motif	0.7568
p.S616N	COLO-320-HSR	large intestine	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.1389
p.G289R	UACC-62	skin	COSMIC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7568
p.R463H	RKO	large intestine	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation altering degron motif	0.8244
p.S475N	NCI-H2227	lung	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	462:469	Mutation rewiring degron network	0.1667
p.M607V	HCC-44	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation altering degron motif	0.7208
p.S606N	COLO-320-HSR	large intestine	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation altering degron motif	0.7069
p.Q318L	HCC-15	lung	COSMIC	PWSST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.Q613L	HCC-15	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	602:609	Mutation rewiring degron network	0.2222
p.M288V	HCC-44	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7208
p.E45K	UACC-893	breast	COSMIC	ISKTPSKE	DEG_SCF_FBW7_2	32:39	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

R3HDM2

UniProt ID: Q9Y2K5

Entrez ID: 22864

Protein name: R3H domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for R3HDM2 in