DegronMD

Uniprot ID: Q9Y2K5

Source protein: R3H domain-containing protein 2

Source gene: R3HDM2

Class: DEG_SCF_FBW7_2

Location: 32:39

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 98.2375

COIL: 0.736

CONS_SCORE: 0.3448

DSS_SCORE: 0.4797

HELIX: 0.2356

FCONS_SCORE: 1.0403

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E24K	TCGA-LN-A49L	ESCA	TCGA	ISKTPSKE	DEG_SCF_FBW7_2	0.1111
p.K34N	DO1146	BRCA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	0.5806
p.M23I	DO233189	GACA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	0.0833
p.L32M	DO228985	LICA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	0.711
p.N28K	DO229035	LICA	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	0.3333
p.S49Y	DO219221	LUSC	ICGC	ISKTPSKE	DEG_SCF_FBW7_2	0.0556
p.E42D	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ISKTPSKE	DEG_SCF_FBW7_2	0.25
p.E42D	ACH-000841	Lung Cancer	CCLE	ISKTPSKE	DEG_SCF_FBW7_2	0.25
p.E42D	NCI-H2087	lung	COSMIC	ISKTPSKE	DEG_SCF_FBW7_2	0.25
p.E45K	UACC-893	breast	COSMIC	ISKTPSKE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K5	R3H domain-containing protein 2	DEG_SCF_FBW7_2	32:39	ISKTPSKE	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons