DegronMD

Uniprot ID: Q9Y2K5

Source protein: R3H domain-containing protein 2

Source gene: R3HDM2

Class: DEG_SCF_FBW7_1

Location: 462:469

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 69.6

COIL: 0.8238

CONS_SCORE: 0.4017

DSS_SCORE: 0.5712

HELIX: 0.0401

FCONS_SCORE: 1.104

RIG_SCORE: 0.7382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L467R	DO233081	GACA	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	0.7316
p.M462T	DO38599	STAD	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	0.7423
p.Y459H	DO42280	UCEC	ICGC	LFQTPLIS	DEG_SCF_FBW7_1	0.25
p.P462L	SIDM00318	Kidney Carcinoma	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	0.7582
p.P462L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	0.7582
p.F476V	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	0.1389
p.P463S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	LFQTPLIS	DEG_SCF_FBW7_1	0.6752
p.P463S	NCI-H1755	lung	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	0.6752
p.F463L	ACH-000368	Brain Cancer	CCLE	LFQTPLIS	DEG_SCF_FBW7_1	0.587
p.R463H	RKO	large_intestine	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	0.8244
p.S475N	NCI-H2227	lung	COSMIC	LFQTPLIS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K5	R3H domain-containing protein 2	DEG_SCF_FBW7_1	462:469	LFQTPLIS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons