DegronMD

Uniprot ID: Q9Y2K5

Source protein: R3H domain-containing protein 2

Source gene: R3HDM2

Class: DEG_SCF_FBW7_1

Location: 602:609

E3 ligase: FBXW7

DEGRON score: 0.9851

ASA_SCORE: 77.5875

COIL: 0.824

CONS_SCORE: 0.3528

DSS_SCORE: 0.3498

HELIX: 0.0169

FCONS_SCORE: 1.0111

RIG_SCORE: 0.7514

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P613S	TCGA-55-7576	LUAD	TCGA	VQYTPLPS	DEG_SCF_FBW7_1	0.2222
p.P613S	DO24431	LUAD	ICGC	VQYTPLPS	DEG_SCF_FBW7_1	0.2222
p.Q596H	TCGA-69-7979	LUAD	TCGA	VQYTPLPS	DEG_SCF_FBW7_1	0.1667
p.G599D	DO23548	LIRI	ICGC	VQYTPLPS	DEG_SCF_FBW7_1	0.25
p.G595S	ACH-000220	Lymphoma	CCLE	VQYTPLPS	DEG_SCF_FBW7_1	0.1389
p.G594R	ACH-000425	Skin Cancer	CCLE	VQYTPLPS	DEG_SCF_FBW7_1	0.1111
p.G594R	UACC-62	skin	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.1111
p.M593V	HCC-44	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.0833
p.G608R	UACC-62	skin	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.7568
p.S616N	COLO-320-HSR	large_intestine	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.1389
p.M607V	HCC-44	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.7208
p.S606N	COLO-320-HSR	large_intestine	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.7069
p.Q613L	HCC-15	lung	COSMIC	VQYTPLPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K5	R3H domain-containing protein 2	DEG_SCF_FBW7_1	602:609	VQYTPLPS	FBXW7	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons