DegronMD

Uniprot ID: Q9Y2K5

Source protein: R3H domain-containing protein 2

Source gene: R3HDM2

Class: DEG_SPOP_SBC_1

Location: 286:290

E3 ligase: SPOP

DEGRON score: 0.8107

ASA_SCORE: 77.12

COIL: 0.603

CONS_SCORE: 0.3707

DSS_SCORE: 0.4779

HELIX: 0.3796

FCONS_SCORE: 1.0085

RIG_SCORE: 0.6519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E285K	DO234411	ESAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.Q283K	DO229029	LICA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.P278H	DO42568	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.E288D	DO41199	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.6758
p.S288Y	SIDM00193	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.712
p.S288Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.712
p.S288Y	SNU-81	large_intestine	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.712
p.G289R	UACC-62	skin	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.7568
p.M288V	HCC-44	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons