DegronMD - O75410(TACC1)

TACC1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A547V	TCGA-AN-A0XP	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.5825
p.E556K	TCGA-CV-7248	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.G554S	DO36030	PBCA	ICGC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.S542F	SIDM00333	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.S542F	ACH-000988	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.S542F	MFE-319	endometrium	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.P540L	SIDM01059	Melanoma	GDSC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P540L	ACH-000915	Skin Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P540L	IPC-298	skin	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.K560E	SW780	urinary tract	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.T558P	NCI-H2196	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.L542F	SKG-IIIa	cervix	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.K561E	SW780	urinary tract	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0556
p.T557P	NCI-H2196	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	547:551	Mutation substituting flanking lysine	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc