DegronMD

Uniprot ID: O75410

Source protein: Transforming acidic coiled-coil-containing protein 1

Source gene: TACC1

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.8702

ASA_SCORE: 71.52

COIL: 0.7828

CONS_SCORE: 0.2265

DSS_SCORE: 0.4523

HELIX: 0.1728

FCONS_SCORE: 0.8284

RIG_SCORE: 0.7218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A547V	TCGA-AN-A0XP	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.5825
p.E556K	TCGA-CV-7248	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1944
p.G554S	DO36030	PBCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.S542F	SIDM00333	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.S542F	ACH-000988	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1944
p.S542F	MFE-319	endometrium	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.P540L	SIDM01059	Melanoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P540L	ACH-000915	Skin Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P540L	IPC-298	skin	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.K560E	SW780	urinary_tract	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0833
p.T558P	NCI-H2196	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.L542F	SKG-IIIa	cervix	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.K561E	SW780	urinary_tract	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.T557P	NCI-H2196	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons