DegronMD - P08235(NR3C2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T364M	TCGA-5L-AAT1	BRCA	TCGA	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.T364M	TCGA-69-8255	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.T364M	DO219594	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.T364M	DO25360	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.C410F	TCGA-A5-A0G1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.C410F	DO42472	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.G404R	TCGA-A5-A0G1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.G404R	DO42472	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.T100I	TCGA-A5-A0G1	UCEC	TCGA	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.T100I	DO42472	UCEC	ICGC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.S407T	TCGA-A8-A07L	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6005
p.S407T	DO2377	BRCA	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6005
p.T348I	TCGA-AB-2808	LAML	TCGA	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2778
p.T348I	DO21487	LAML	ICGC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2778
p.R162I	TCGA-AX-A2HC	UCEC	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.6991
p.R162I	DO41572	UCEC	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.6991
p.A115V	TCGA-BH-A0HB	BRCA	TCGA	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.A115V	DO1354	BRCA	ICGC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.S419L	TCGA-BS-A0UV	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.S419L	TCGA-FW-A3R5	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.S419L	DO220891	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.S419L	DO37406	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.S419L	DO42793	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.V172M	TCGA-CD-A4MI	STAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.0833
p.V172M	DO47717	STAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.0833
p.P160L	TCGA-CG-4306	STAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7582
p.P160L	DO38567	STAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.7582
p.R113K	TCGA-D1-A17H	UCEC	TCGA	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.25
p.R113K	DO41847	UCEC	ICGC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.25
p.G169R	TCGA-DA-A1I1	SKCM	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.G169R	DO37966	SKCM	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.S407R	TCGA-E6-A1LX	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7427
p.S407R	DO41020	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7427
p.P151L	TCGA-EB-A5UL	SKCM	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.P151L	DO47601	SKCM	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1667
p.K399Q	TCGA-EO-A22X	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation substituting flanking lysine	0.2778
p.K399Q	DO43907	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation substituting flanking lysine	0.2778
p.S168C	TCGA-MP-A4SV	LUAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation blocking phosphorylation signal	0.6389
p.S168C	DO45339	LUAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation blocking phosphorylation signal	0.6389
p.L411V	TCGA-P3-A5QF	HNSC	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.L411V	DO44439	HNSC	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.Y397C	TCGA-XK-AAIW	PRAD	TCGA	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1111
p.Y397C	DO51407	PRAD	ICGC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1111
p.D110N	DO1153	BRCA	ICGC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6932
p.G347C	DO231939	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.25
p.D114N	DO222363	MELA	ICGC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2222
p.G412R	SIDM01169	Ovarian Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.G412R	ACH-000885	Ovarian Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.G412R	TOV-21G	ovary	COSMIC	AFSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.R150H	SIDM00569	Osteosarcoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1389
p.R150H	SIDM00587	Biliary Tract Carcinoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1389
p.R150H	SIDM01559	Melanoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1389
p.R150H	SIDM01434	Hepatocellular Carcinoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1389
p.A99V	SIDM00660	Colorectal Carcinoma	GDSC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.A99V	ACH-000985	Colon/Colorectal Cancer	CCLE	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.A99V	LS-411N	large intestine	COSMIC	MGLYMD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.S342N	SIDM00346	Chronic Myelogenous Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S342N	ACH-000301	Leukemia	CCLE	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S342N	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1111
p.S353T	SIDM00254	Neuroblastoma	GDSC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.S353T	ACH-002283	Neuroblastoma	CCLE	AGSST	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.S353T	NB5	autonomic ganglia	COSMIC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6005
p.T364P	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.T364P	ACH-000388	Lymphoma	CCLE	AGSST	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR3C2

UniProt ID: P08235

Entrez ID: 4306

Protein name: Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR3C2 in