DegronMD

Uniprot ID: P08235

Source protein: Mineralocorticoid receptor

Source gene: NR3C2

Class: LIG_APCC_ABBA_1

Location: 105:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5606

ASA_SCORE: 60.8833

COIL: 0.5442

CONS_SCORE: 0.5928

DSS_SCORE: 0.357

HELIX: 0.3783

FCONS_SCORE: 1.2447

RIG_SCORE: 0.766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T100I	TCGA-A5-A0G1	UCEC	TCGA	MGLYMD	LIG_APCC_ABBA_1	0.1944
p.T100I	DO42472	UCEC	ICGC	MGLYMD	LIG_APCC_ABBA_1	0.1944
p.A115V	TCGA-BH-A0HB	BRCA	TCGA	MGLYMD	LIG_APCC_ABBA_1	0.1944
p.A115V	DO1354	BRCA	ICGC	MGLYMD	LIG_APCC_ABBA_1	0.1944
p.R113K	TCGA-D1-A17H	UCEC	TCGA	MGLYMD	LIG_APCC_ABBA_1	0.25
p.R113K	DO41847	UCEC	ICGC	MGLYMD	LIG_APCC_ABBA_1	0.25
p.D110N	DO1153	BRCA	ICGC	MGLYMD	LIG_APCC_ABBA_1	0.6932
p.D114N	DO222363	MELA	ICGC	MGLYMD	LIG_APCC_ABBA_1	0.2222
p.A99V	SIDM00660	Colorectal Carcinoma	GDSC	MGLYMD	LIG_APCC_ABBA_1	0.1667
p.A99V	ACH-000985	Colon/Colorectal Cancer	CCLE	MGLYMD	LIG_APCC_ABBA_1	0.1667
p.A99V	LS-411N	large_intestine	COSMIC	MGLYMD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08235	Mineralocorticoid receptor	LIG_APCC_ABBA_1	105:110	MGLYMD	APC,CDC20,FZR1	0.5606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons