DegronMD

Uniprot ID: P08235

Source protein: Mineralocorticoid receptor

Source gene: NR3C2

Class: DEG_SPOP_SBC_1

Location: 350:354

E3 ligase: SPOP

DEGRON score: 0.7056

ASA_SCORE: 54.8

COIL: 0.6944

CONS_SCORE: 0.4981

DSS_SCORE: 0.4811

HELIX: 0.2128

FCONS_SCORE: 1.0123

RIG_SCORE: 0.6131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T364M	TCGA-5L-AAT1	BRCA	TCGA	AGSST	DEG_SPOP_SBC_1	0.0556
p.T364M	TCGA-69-8255	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	0.0556
p.T364M	DO219594	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.0556
p.T364M	DO25360	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.0556
p.T348I	TCGA-AB-2808	LAML	TCGA	AGSST	DEG_SPOP_SBC_1	0.2778
p.T348I	DO21487	LAML	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.G347C	DO231939	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.S342N	SIDM00346	Chronic Myelogenous Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S342N	ACH-000301	Leukemia	CCLE	AGSST	DEG_SPOP_SBC_1	0.1111
p.S342N	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S353T	SIDM00254	Neuroblastoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.6005
p.S353T	ACH-002283	Neuroblastoma	CCLE	AGSST	DEG_SPOP_SBC_1	0.6005
p.S353T	NB5	autonomic_ganglia	COSMIC	AGSST	DEG_SPOP_SBC_1	0.6005
p.T364P	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0556
p.T364P	ACH-000388	Lymphoma	CCLE	AGSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons