DegronMD - O14641(DVL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G12V	TCGA-55-8506	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.G12V	DO45390	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.P565H	TCGA-AX-A1CE	UCEC	TCGA	PPPY	ITCH	565:568	Mutation altering degron motif	0.7694
p.P565H	DO42280	UCEC	ICGC	PPPY	ITCH	565:568	Mutation altering degron motif	0.7694
p.P558S	TCGA-B5-A3FA	UCEC	TCGA	PPPY	ITCH	565:568	Mutation rewiring degron network	0.1389
p.P558S	DO52402	UCEC	ICGC	PPPY	ITCH	565:568	Mutation rewiring degron network	0.1389
p.G395D	TCGA-CG-5728	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6087
p.G395D	DO38619	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6087
p.S398F	TCGA-CR-7388	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.7982
p.S398F	DO14284	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.7982
p.S418P	TCGA-CZ-5455	KIRC	TCGA	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation altering degron motif	0.6752
p.S418P	DO19078	KIRC	ICGC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation altering degron motif	0.6752
p.G578V	TCGA-D3-A2J6	SKCM	TCGA	PPPY	ITCH	565:568	Mutation rewiring degron network	0.0556
p.G578V	DO37901	SKCM	ICGC	PPPY	ITCH	565:568	Mutation rewiring degron network	0.0556
p.G578W	TCGA-D3-A2JN	SKCM	TCGA	PPPY	ITCH	565:568	Mutation rewiring degron network	0.0556
p.G578W	DO47590	SKCM	ICGC	PPPY	ITCH	565:568	Mutation rewiring degron network	0.0556
p.E13D	TCGA-DK-AA71	BLCA	TCGA	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.E13D	DO219010	BLCA	ICGC	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.S562N	TCGA-G4-6302	COAD	TCGA	PPPY	ITCH	565:568	Mutation rewiring degron network	0.25
p.S562N	DO8778	COAD	ICGC	PPPY	ITCH	565:568	Mutation rewiring degron network	0.25
p.S397F	TCGA-GD-A3OP	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.7982
p.S397F	DO761	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.7982
p.P409S	TCGA-IB-7651	PAAD	TCGA	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation rewiring degron network	0.1111
p.P409S	DO46657	PAAD	ICGC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation rewiring degron network	0.1111
p.G12E	TCGA-KK-A5A1	PRAD	TCGA	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.G12E	DO49845	PRAD	ICGC	AGSST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.T387N	DO228976	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1389
p.P394Q	DO229036	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.7035
p.M399V	DO229047	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01146	Gastric Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM00612	Glioma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01210	Glioblastoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01612	Endometrial Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01577	Plasma Cell Myeloma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM01393	Gastric Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.M399V	SIDM00164	Biliary Tract Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.T6N	DO229063	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7055
p.Q564H	DO232018	ORCA	ICGC	PPPY	ITCH	565:568	Mutation rewiring degron network	0.3056
p.V419I	SIDM00518	Mesothelioma	GDSC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation altering degron motif	0.5965
p.A424T	SIDM00151	Ovarian Carcinoma	GDSC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation rewiring degron network	0.2778
p.A424T	ACH-000966	Ovarian Cancer	CCLE	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation rewiring degron network	0.2778
p.A424T	IGROV-1	ovary	COSMIC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation rewiring degron network	0.2778
p.A418T	IGROV-1	ovary	COSMIC	LSVHTD	LIG_APCC_ABBA_1	417:422	Mutation altering degron motif	0.7139

Kaplan plot for DVL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DVL2

UniProt ID: O14641

Entrez ID: 1856

Protein name: Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DVL2 in