DegronMD

Uniprot ID: O14641

Source protein: Segment polarity protein dishevelled homolog DVL-2

Source gene: DVL2

Class: LIG_APCC_ABBA_1

Location: 417:422

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9978

ASA_SCORE: 60.8833

COIL: 0.787

CONS_SCORE: 0.498

DSS_SCORE: 0.4513

HELIX: 0.0817

FCONS_SCORE: 1.0138

RIG_SCORE: 0.7286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S418P	TCGA-CZ-5455	KIRC	TCGA	LSVHTD	LIG_APCC_ABBA_1	0.6752
p.S418P	DO19078	KIRC	ICGC	LSVHTD	LIG_APCC_ABBA_1	0.6752
p.P409S	TCGA-IB-7651	PAAD	TCGA	LSVHTD	LIG_APCC_ABBA_1	0.1111
p.P409S	DO46657	PAAD	ICGC	LSVHTD	LIG_APCC_ABBA_1	0.1111
p.V419I	SIDM00518	Mesothelioma	GDSC	LSVHTD	LIG_APCC_ABBA_1	0.5965
p.A424T	SIDM00151	Ovarian Carcinoma	GDSC	LSVHTD	LIG_APCC_ABBA_1	0.2778
p.A424T	ACH-000966	Ovarian Cancer	CCLE	LSVHTD	LIG_APCC_ABBA_1	0.2778
p.A424T	IGROV-1	ovary	COSMIC	LSVHTD	LIG_APCC_ABBA_1	0.2778
p.A418T	IGROV-1	ovary	COSMIC	LSVHTD	LIG_APCC_ABBA_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	LIG_APCC_ABBA_1	417:422	LSVHTD	APC,CDC20,FZR1	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons