DegronMD - P51532(SMARCA4)

FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1241Q	TCGA-24-2261	OV	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.2778
p.H1241Q	DO28551	OV	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.2778
p.E1242K	TCGA-43-5670	LUSC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.E1242K	DO26434	LUSC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.3056
p.Q1248H	TCGA-55-8089	LUAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.647
p.Q1248H	DO23690	LUAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.647
p.R1411Q	TCGA-A5-A0GB	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1111
p.F1271L	TCGA-AA-3492	COAD	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.1944
p.F1271L	DO8224	COAD	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.1944
p.R1243Q	TCGA-AA-3527	COAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6218
p.R1243Q	DO9090	COAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6218
p.R1413C	TCGA-AD-6889	COAD	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1413C	DO8463	COAD	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1244P	TCGA-B9-5156	KIRP	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7512
p.R1244P	DO20774	KIRP	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7512
p.E1254D	TCGA-BG-A220	UCEC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.25
p.E1254D	DO41784	UCEC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.25
p.R1243W	TCGA-BP-4964	KIRC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	TCGA-BS-A0V4	UCEC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	TCGA-IC-A6RF	ESCA	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO233737	GACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO16263	KIRC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO27795	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO228368	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO33704	PACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO35442	PACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO228138	PBCA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO227845	PBCA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.R1243W	DO42969	UCEC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7523
p.H1261Y	TCGA-CK-4951	COAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.H1261Y	DO10582	COAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.S1410L	TCGA-CQ-5326	HNSC	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation blocking phosphorylation signal	0.5278
p.S1410L	DO15286	HNSC	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation blocking phosphorylation signal	0.5278
p.S1422F	TCGA-CV-7568	HNSC	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.9093
p.S1422F	DO14160	HNSC	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.9093
p.G1280C	TCGA-DK-A3IL	BLCA	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.6489
p.G1280C	DO555	BLCA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.6489
p.F1234L	TCGA-DU-7018	LGG	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0833
p.F1234L	DO22223	LGG	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0833
p.F1234L	DO222402	MELA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0833
p.D1418N	TCGA-EE-A29E	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418N	TCGA-EE-A29E	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.D1418N	IGROV-1	ovary	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418N	IGROV-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.K1291N	TCGA-EE-A29Q	SKCM	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation substituting flanking lysine	0.25
p.K1291N	DO37866	SKCM	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation substituting flanking lysine	0.25
p.P1424S	TCGA-EE-A2A6	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.6752
p.P305T	TCGA-EE-A2MR	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.P305T	DO37819	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.R1411W	TCGA-F1-6874	STAD	TCGA	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1111
p.E1436D	TCGA-FJ-A3ZF	BLCA	TCGA	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1111
p.P1277L	TCGA-HU-A4G8	STAD	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7582
p.P1277L	DO47819	STAD	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7582
p.W284L	TCGA-HU-A4H4	STAD	TCGA	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.W284L	DO50699	ORCA	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.W284L	DO47721	STAD	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.R1244G	TCGA-MP-A4SY	LUAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7568
p.R1244G	DO45398	LUAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.7568
p.A1272T	TCGA-VQ-A8P2	STAD	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.2222
p.A1272T	DO51761	STAD	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.2222
p.D1284N	TCGA-ZF-A9RF	BLCA	TCGA	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.5821
p.D1284N	DO219074	BLCA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.5821
p.M1286T	DO224865	BRCA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.2778
p.A1269V	DO230309	COCA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.1389
p.A292T	DO234230	ESAD	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2778
p.A1279V	DO234374	ESAD	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.6936
p.M1233T	DO234417	ESAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.R1413H	DO233261	GACA	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.V1281I	DO233888	GACA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7076
p.K1237E	DO233804	GACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation blocking ubiquitination signal	0.6111
p.E1277K	DO13462	GBM	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7022
p.E1267D	DO219080	HNSC	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.0833
p.E1278K	DO219080	HNSC	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7022
p.K301N	DO228937	LICA	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation substituting flanking lysine	0.3611
p.Q1415H	DO229019	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.2222
p.Q1415H	DO229019	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.0833
p.V1281F	DO229035	LICA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7068
p.E1267K	DO25059	LUAD	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.0833
p.P307S	DO224610	LUSC	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.R1429H	DO228338	MALY	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1429H	DO228338	MALY	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.3056
p.R1429H	SIDM00948	Burkitt's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1429H	SIDM00948	Burkitt's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.3056
p.R1429H	ACH-002232	Lymphoma	CCLE	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1429H	ACH-002232	Lymphoma	CCLE	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.3056
p.R1429H	DG-75	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1667
p.R1429H	DG-75	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.3056
p.S1239P	DO228419	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.2222
p.PP304PS	DO222363	MELA	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0
p.P238S	DO222516	MELA	ICGC	PPNY	ITCH	246:249	Mutation rewiring degron network	0.1111
p.E1279V	DO27985	OV	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation altering degron motif	0.7693
p.R1275W	DO32887	PACA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.3056
p.R1292C	DO232224	PBCA	ICGC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.1111
p.A1438V	DO37531	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation substituting flanking lysine	0.1667
p.A1438V	DO37404	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation substituting flanking lysine	0.1667
p.P1423H	DO37896	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.7694
p.P1425Q	DO37456	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.7035
p.L302P	DO229133	THCA	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.R1419S	DO229257	THCA	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.7427
p.A293T	DO229095	THCA	ICGC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R1419H	DO42312	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.8244
p.P1425S	DO41014	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.6752
p.P1425S	PCI-4B	upper aerodigestive tract	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.6752
p.K1409Q	DO43041	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.0556
p.H1253Y	SIDM02036	Esophageal Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.2778
p.R1244H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8244
p.R1244H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8244
p.R1244H	ACH-000995	Leukemia	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8244
p.R1244H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8244
p.S1409T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.0556
p.S1409T	ACH-000981	Leukemia	CCLE	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.0556
p.S1409T	DND-41	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.0556
p.P285T	SIDM00607	Glioblastoma	GDSC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.P285T	ACH-000622	Brain Cancer	CCLE	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.P285T	KNS-42	central nervous system	COSMIC	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.Q1248R	SIDM00889	Cervical Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6218
p.Q1248R	ACH-001333	Cervical Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6218
p.Q1248R	C-33-A	cervix	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6218
p.D1418Y	SIDM00523	Small Cell Lung Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418Y	SIDM00523	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.D1418Y	ACH-000698	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418Y	ACH-000698	Lung Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.D1418Y	DMS-53	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418Y	DMS-53	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.D1235Y	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.D1235Y	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.D1235Y	ACH-000823	Esophageal Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.D1235Y	ACH-000945	Lung Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.D1235Y	NCI-H650	lung	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.D1235Y	KYSE-140	oesophagus	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1111
p.R1244C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.8301
p.D1416N	SIDM00151	Ovarian Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.25
p.D1416N	SIDM00151	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1111
p.D1416N	ACH-000966	Ovarian Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.25
p.D1416N	ACH-000966	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1111
p.D1416N	IGROV-1	ovary	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.25
p.D1416N	IGROV-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1111
p.M1233I	SIDM00516	Melanoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.M1233I	ACH-002166	Skin Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.M1233I	MZ7-mel	skin	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.0556
p.G256R	SIDM00217	Colorectal Carcinoma	GDSC	PPNY	ITCH	246:249	Mutation rewiring degron network	0.1389
p.G256R	ACH-000999	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	246:249	Mutation rewiring degron network	0.1389
p.G256R	SNU-1040	large intestine	COSMIC	PPNY	ITCH	246:249	Mutation rewiring degron network	0.1389
p.M289T	ACH-000930	Breast Cancer	CCLE	APTST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.A245V	ACH-000964	Leukemia	CCLE	PPNY	ITCH	246:249	Mutation rewiring degron network	0.3056
p.P236L	ACH-002024	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	246:249	Mutation rewiring degron network	0.0556
p.A1250V	SNU-C2B	large intestine	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation altering degron motif	0.6936
p.R1415W	639-V	urinary tract	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.2222
p.R1415W	639-V	urinary tract	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.0833
p.R1415W	CCK-81	large intestine	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.2222
p.R1415W	CCK-81	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.0833
p.A1435G	SNU-175	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1389
p.D1418E	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.3056
p.D1418E	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.1667
p.R1428H	DG-75	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.8244
p.R1412W	639-V	urinary tract	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation substituting flanking lysine	0.25
p.R1412W	CCK-81	large intestine	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation substituting flanking lysine	0.25
p.V1271I	KYSE-410	oesophagus	COSMIC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.1944
p.R1256C	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1944
p.D1420E	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.6758
p.N1424H	T-T	oesophagus	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.7423
p.P1423L	AN3-CA	endometrium	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.7582
p.R1431H	DG-75	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1111
p.R1431H	DG-75	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.25
p.S1411T	DND-41	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.1111
p.N1421H	T-T	oesophagus	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.7423
p.R1267H	639-V	urinary tract	COSMIC	PPPAGVNPD	DEG_SIAH_1	1276:1284	Mutation rewiring degron network	0.0833
p.D1417E	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation blocking phosphorylation signal	0.7222
p.D1417E	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation blocking phosphorylation signal	0.5833
p.P1422S	PCI-4B	upper aerodigestive tract	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.6752
p.P1426L	AN3-CA	endometrium	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation altering degron motif	0.7582
p.D1415N	IGROV-1	ovary	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation rewiring degron network	0.2222
p.D1415N	IGROV-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation rewiring degron network	0.0833
p.A1438G	SNU-175	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation substituting flanking lysine	0.1667
p.D1417Y	DMS-53	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation blocking phosphorylation signal	0.7222
p.D1417Y	DMS-53	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	1424:1428	Mutation blocking phosphorylation signal	0.5833
p.R1256H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	1243:1251	Mutation rewiring degron network	0.1944
p.D1420Y	DMS-53	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	1419:1423	Mutation altering degron motif	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCA4

UniProt ID: P51532

Entrez ID: 6597

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCA4 in