DegronMD

Uniprot ID: P51532

Source protein: Transcription activator BRG1

Source gene: SMARCA4

Class: DEG_SPOP_SBC_1

Location: 1424:1428

E3 ligase: SPOP

DEGRON score: 0.6708

ASA_SCORE: 87.04

COIL: 0.8942

CONS_SCORE: 0.3087

DSS_SCORE: 0.7631

HELIX: 0.088

FCONS_SCORE: 0.9707

RIG_SCORE: 0.5467

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1428H	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.8244
p.P1426L	AN3-CA	endometrium	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7582
p.N1424H	T-T	oesophagus	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7423
p.P1425Q	DO37456	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.7035
p.P1424S	TCGA-EE-A2A6	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	0.6752
p.P1425S	DO41014	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.6752
p.P1425S	PCI-4B	upper_aerodigestive_tract	COSMIC	PTTST	DEG_SPOP_SBC_1	0.6752
p.D1417E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.5833
p.D1417Y	DMS-53	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.5833
p.R1429H	DO228338	MALY	ICGC	PTTST	DEG_SPOP_SBC_1	0.3056
p.R1429H	SIDM00948	Burkitt's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.3056
p.R1429H	ACH-002232	Lymphoma	CCLE	PTTST	DEG_SPOP_SBC_1	0.3056
p.R1429H	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.3056
p.R1431H	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.25
p.D1418N	TCGA-EE-A29E	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	0.1667
p.D1418N	IGROV-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.A1438V	DO37531	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.1667
p.A1438V	DO37404	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.1667
p.D1418Y	SIDM00523	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1667
p.D1418Y	ACH-000698	Lung Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1667
p.D1418Y	DMS-53	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.D1418E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.A1438G	SNU-175	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.A1435G	SNU-175	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1389
p.E1436D	TCGA-FJ-A3ZF	BLCA	TCGA	PTTST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 25 of 32 entries

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Drug responses associated with SMARCA4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI-3	48.5692
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI3	22.895
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI-3	42.4835
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI3	91.199
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI-3	37.5832
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI3	137.96
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI3	44.829
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI3	44.829
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI-3	40.2331
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI3	54.548
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI-3	87.363
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI3	142.58
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI3	72.351
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI3	72.351
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI3	139.3
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI3	139.3
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI-3	81.8615
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI3	156.34
SIDM00889	CESC\|cervix	p.N772_L773insN (No)	GDSC	PFI-3	59.1782

Showing 1 to 25 of 230 entries

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All proteins holding degron of PTTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...

Showing 1 to 16 of 16 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTST

Degron related mutations and impact score

Drug responses associated with SMARCA4 mutations

All proteins holding degron of PTTST