DegronMD - Q6ZSZ6(TSHZ1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G503V	TCGA-37-A5EN	LUSC	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.K501N	TCGA-44-6778	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1667
p.K501N	TCGA-64-5779	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1667
p.D497Y	TCGA-49-AAR9	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.P725L	TCGA-55-8514	LUAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.0833
p.P718L	TCGA-55-8620	LUAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.2778
p.Q856L	TCGA-56-8307	LUSC	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.7765
p.Q856L	TCGA-56-8307	LUSC	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7765
p.S485I	TCGA-A5-A0G2	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation substituting flanking lysine	0.2778
p.D724N	TCGA-AA-3715	COAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1111
p.P849L	TCGA-AP-A1DV	UCEC	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.2778
p.P849L	TCGA-AP-A1DV	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.2222
p.P484T	TCGA-BG-A222	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation substituting flanking lysine	0.25
p.L855M	TCGA-BK-A13B	UCEC	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.711
p.L855M	TCGA-BK-A13B	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.711
p.N848S	TCGA-CM-6678	COAD	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.25
p.N848S	TCGA-CM-6678	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.1944
p.N848S	DO10220	COAD	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.25
p.N848S	DO10220	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.1944
p.E494D	TCGA-DF-A2KN	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6758
p.E494D	LS-180	large intestine	COSMIC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6758
p.P489L	TCGA-DF-A2KU	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.7222
p.T866I	TCGA-EB-A44P	SKCM	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0556
p.T866I	TCGA-EB-A44P	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.G842V	TCGA-NC-A5HJ	LUSC	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0833
p.G842V	DO219189	LUSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0833
p.R864W	TCGA-WS-AB45	COAD	TCGA	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation substituting flanking lysine	0.2222
p.R864W	TCGA-WS-AB45	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	853:857	Mutation substituting flanking lysine	0.25
p.R864W	DO51734	COAD	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation substituting flanking lysine	0.2222
p.R864W	DO51734	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation substituting flanking lysine	0.25
p.R864W	LS-411N	large intestine	COSMIC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation substituting flanking lysine	0.2222
p.R864W	LS-411N	large intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation substituting flanking lysine	0.25
p.V844L	DO227944	BRCA	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.1389
p.V844L	DO227944	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.S856F	DO223732	CESC	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.7982
p.S856F	DO223732	CESC	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7982
p.H155N	DO8730	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.N846S	DO230311	COCA	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.1944
p.N846S	DO230311	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.1389
p.T494M	DO222755	COCA	ICGC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7423
p.L666P	DO229010	COCA	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1111
p.L666P	DO234285	ESAD	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1111
p.L666P	DO229480	LAML	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1111
p.L666P	DO229505	LAML	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1111
p.T159P	DO223098	ESCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.T159P	DO229208	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.T159P	DO229211	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.T159P	DO229250	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.A702T	DO218693	GACA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1111
p.R864Q	DO233262	GACA	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation substituting flanking lysine	0.2222
p.R864Q	DO233262	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation substituting flanking lysine	0.25
p.S176N	DO233277	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.S176N	DO233277	GACA	ICGC	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2778
p.T857M	DO233652	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7423
p.S154F	DO233702	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.S154F	SIDM00007	Other Solid Cancers	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.L851Q	DO15999	HNSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.7765
p.A669T	DO16037	HNSC	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1944
p.A702V	DO22237	LGG	ICGC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1111
p.P713L	DO229019	LICA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation altering degron motif	0.7582
p.G688C	DO229037	LICA	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.0556
p.K854N	DO229037	LICA	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.5806
p.K854N	DO229037	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.5806
p.D842N	DO231191	LUSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0833
p.P672H	DO26898	LUSC	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.2778
p.G492V	DO26590	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6421
p.G700W	DO26467	LUSC	ICGC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.0556
p.S481F	DO222632	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.P700Q	DO32980	PACA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.0556
p.S687I	DO220011	SARC	ICGC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.0833
p.T162P	DO229191	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.T162P	DO229191	THCA	ICGC	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.T162P	DO229204	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.T162P	DO229204	THCA	ICGC	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.T162P	DO229232	THCA	ICGC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.T162P	DO229232	THCA	ICGC	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.S482G	DO48173	UCEC	ICGC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.5278
p.P156T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM01169	Ovarian Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM00504	Glioma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM00197	Ewing's Sarcoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM00507	Other Solid Cancers	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM00142	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P156T	SIDM01592	Breast Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.T683M	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1944
p.T683M	SIDM01164	Glioma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1944
p.T683M	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.1944
p.K678E	SIDM00698	Small Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation altering degron motif	0.591
p.K678E	ACH-000506	Lung Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation altering degron motif	0.591
p.K678E	NCI-H146	lung	COSMIC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation altering degron motif	0.591
p.S181F	SIDM00007	Other Solid Cancers	GDSC	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.S181F	ACH-001550	Skin Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T852S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.8227
p.T852S	ACH-000757	Lung Cancer	CCLE	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.8227
p.T852S	A427	lung	COSMIC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation altering degron motif	0.8227
p.S865F	SIDM00210	Ovarian Carcinoma	GDSC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0833
p.S865F	SIDM00210	Ovarian Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.1111
p.S865F	A2780	ovary	COSMIC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.0833
p.S865F	A2780	ovary	COSMIC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.1111
p.T168I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7078
p.T168I	SIDM00537	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7078
p.E705K	SIDM00003	Melanoma	GDSC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1944
p.E705K	ACH-002159	Skin Cancer	CCLE	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1944
p.E705K	M14	skin	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.1944
p.T157I	SIDM00828	Other Sarcomas	GDSC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.P681L	SIDM01107	Melanoma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.25
p.P681L	SIDM00900	Non-Cancerous	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.25
p.P681L	SIDM01397	Melanoma	GDSC	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.25
p.S489C	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.7222
p.S489C	ACH-000287	Lymphoma	CCLE	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.7222
p.S489C	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.7222
p.C179Y	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.V861A	ACH-001385	Head and Neck Cancer	CCLE	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.1944
p.V861A	ACH-001385	Head and Neck Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.2222
p.V861A	RPMI-2650	upper aerodigestive tract	COSMIC	LTPKSS	DEG_SCF_FBW7_1	851:856	Mutation rewiring degron network	0.1944
p.V861A	RPMI-2650	upper aerodigestive tract	COSMIC	PKSST	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.2222
p.A670V	ACH-001610	Brain Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.2222
p.P681S	ACH-001656	Leukemia	CCLE	AKENK	DEG_APCC_KENBOX_2	674:678	Mutation rewiring degron network	0.25
p.Y490F	MCC13	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.3056
p.V719M	22RV1	prostate	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.25
p.T166M	TGBC11TKB	stomach	COSMIC	PVSTT	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7423
p.V719L	BICR22	upper aerodigestive tract	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	710:716	Mutation rewiring degron network	0.25
p.P500R	SW1271	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	491:495	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSHZ1

UniProt ID: Q6ZSZ6

Entrez ID: 10194

Protein name: Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TSHZ1 in