DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_SPOP_SBC_1

Location: 853:857

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 102.54

COIL: 0.9542

CONS_SCORE: 0.3533

DSS_SCORE: 0.5875

HELIX: 0.0186

FCONS_SCORE: 0.7116

RIG_SCORE: 0.5985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q856L	TCGA-56-8307	LUSC	TCGA	PKSST	DEG_SPOP_SBC_1	0.7765
p.P849L	TCGA-AP-A1DV	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.2222
p.L855M	TCGA-BK-A13B	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.711
p.N848S	TCGA-CM-6678	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.1944
p.N848S	DO10220	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.1944
p.T866I	TCGA-EB-A44P	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	0.0833
p.R864W	TCGA-WS-AB45	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.25
p.R864W	DO51734	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.25
p.R864W	LS-411N	large_intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	0.25
p.V844L	DO227944	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.S856F	DO223732	CESC	ICGC	PKSST	DEG_SPOP_SBC_1	0.7982
p.N846S	DO230311	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1389
p.R864Q	DO233262	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	0.25
p.T857M	DO233652	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	0.7423
p.K854N	DO229037	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.5806
p.S865F	SIDM00210	Ovarian Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.1111
p.S865F	A2780	ovary	COSMIC	PKSST	DEG_SPOP_SBC_1	0.1111
p.V861A	ACH-001385	Head and Neck Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.2222
p.V861A	RPMI-2650	upper_aerodigestive_tract	COSMIC	PKSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons