DegronMD

Uniprot ID: Q96AV8

Source protein: Transcription factor E2F7

Source gene: E2F7

Class: DEG_SPOP_SBC_1

Location: 804:808

E3 ligase: SPOP

DEGRON score: 0.9603

ASA_SCORE: 90.12

COIL: 0.9356

CONS_SCORE: 0.2527

DSS_SCORE: 0.5204

HELIX: 0.026

FCONS_SCORE: 1.1123

RIG_SCORE: 0.6717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P814S	TCGA-46-3768	LUSC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.P814S	TCGA-86-A4JF	LUAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.P814S	TCGA-FW-A3R5	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.P814S	DO45317	LUAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.P814S	DO26466	LUSC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.P814S	DO37406	SKCM	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.S807F	TCGA-KO-8408	KICH	TCGA	PKSST	DEG_SPOP_SBC_1	0.7982
p.S807F	DO220562	KICH	ICGC	PKSST	DEG_SPOP_SBC_1	0.7982
p.P810H	DO229015	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.2778
p.S806P	DO23466	LINC	ICGC	PKSST	DEG_SPOP_SBC_1	0.6752
p.P804S	DO229462	SKCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.6752
p.S806L	SIDM02021	Esophageal Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.7667
p.S818I	ACH-001613	Leukemia	CCLE	PKSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons