DegronMD - O60279(SUSD5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K353M	TCGA-39-5031	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.1944
p.K353M	DO26526	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.1944
p.V362L	TCGA-A3-3374	KIRC	TCGA	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.6765
p.L414I	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.L414I	TCGA-CA-6718	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.L414I	DO7801	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.L414I	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.P375H	TCGA-A5-A0G1	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.P375H	TCGA-G7-6797	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.P375H	DO20917	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.P375H	DO42472	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.D360Y	TCGA-A5-A1OF	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.2778
p.D360Y	DO42568	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.2778
p.M431R	TCGA-BA-A6DA	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.M431R	DO44448	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.S422G	TCGA-D1-A16F	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.6993
p.S422G	DO42408	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.6993
p.T424I	TCGA-DF-A2KU	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.7078
p.T424I	DO223286	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.7078
p.L425I	TCGA-EE-A2GE	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.3056
p.L425I	DO38016	SKCM	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.3056
p.M431T	TCGA-EY-A1GQ	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.M431T	DO43090	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.T426K	DO225152	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778
p.E416D	DO229010	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2222
p.V417G	DO233840	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.P375S	DO222407	MELA	ICGC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.A358T	SIDM00889	Cervical Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.2222
p.A358T	ACH-001333	Cervical Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.2222
p.A358T	C-33-A	cervix	COSMIC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.2222
p.S369F	SIDM01398	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.25
p.S369F	ACH-000661	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUSD5

UniProt ID: O60279

Entrez ID: 26032

Protein name: Sushi domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUSD5 in