DegronMD

Uniprot ID: O60279

Source protein: Sushi domain-containing protein 5

Source gene: SUSD5

Class: DEG_SPOP_SBC_1

Location: 420:424

E3 ligase: SPOP

DEGRON score: 0.8629

ASA_SCORE: 92.2

COIL: 0.9156

CONS_SCORE: 0.4129

DSS_SCORE: 0.5611

HELIX: 0.031

FCONS_SCORE: 0.8855

RIG_SCORE: 0.6695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L414I	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.L414I	TCGA-CA-6718	COAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.L414I	DO7801	COAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.L414I	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.M431R	TCGA-BA-A6DA	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1389
p.M431R	DO44448	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1389
p.S422G	TCGA-D1-A16F	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.6993
p.S422G	DO42408	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.6993
p.T424I	TCGA-DF-A2KU	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.7078
p.T424I	DO223286	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.7078
p.L425I	TCGA-EE-A2GE	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	0.3056
p.L425I	DO38016	SKCM	ICGC	PKSST	DEG_SPOP_SBC_1	0.3056
p.M431T	TCGA-EY-A1GQ	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1389
p.M431T	DO43090	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1389
p.T426K	DO225152	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.2778
p.E416D	DO229010	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.2222
p.V417G	DO233840	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons