DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SPOP_SBC_1

Location: 1451:1455

E3 ligase: SPOP

DEGRON score: 0.9939

ASA_SCORE: 104.14

COIL: 0.9712

CONS_SCORE: 0.3584

DSS_SCORE: 0.8197

HELIX: 0.0142

FCONS_SCORE: 1.0502

RIG_SCORE: 0.4674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1455M	TCGA-D7-A6EY	STAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.7423
p.Q1454K	DO48362	BLCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.6944
p.R1451Q	DO1902	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.7329
p.P1453A	DO6494	CLLE	ICGC	PKSST	DEG_SPOP_SBC_1	0.7503
p.E1452D	DO229026	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.6758
p.A1461V	DO26469	LUSC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.A1460T	DO42193	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1944
p.T1448K	DO41050	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.25
p.F1457L	DO41758	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.2778
p.P1443L	SIDM00596	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.1111
p.P1443L	ACH-000941	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.1111
p.P1443L	ACH-000954	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.1111
p.P1443L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.1111
p.P1443L	HEC-1	endometrium	COSMIC	PKSST	DEG_SPOP_SBC_1	0.1111
p.S1454F	SIDM00217	Colorectal Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.7982
p.S1454F	ACH-000999	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.7982
p.S1454F	SNU-1040	large_intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	0.7982
p.P1459S	SIDM01608	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.2222
p.P1459S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons