DegronMD - Q9BSE4(HERPUD2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S103N	TCGA-64-1676	LUAD	TCGA	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2222
p.S103N	DO23629	LUAD	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2222
p.R89Q	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.R89Q	TCGA-B5-A11E	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.R89Q	DO41644	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.R89Q	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.A133V	TCGA-EE-A181	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.A133V	DO37444	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.S98N	TCGA-F7-A624	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7069
p.S98N	DO44440	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7069
p.H104N	TCGA-KQ-A41N	BLCA	TCGA	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.H104N	DO223588	BLCA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.H104N	DO229022	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.A108T	DO49225	ALL	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO229016	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO229005	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO229346	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO230659	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO231140	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO228957	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.A108T	DO218840	SKCA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.R144L	DO48380	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667
p.A106T	DO227829	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1389
p.S131Y	DO228974	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.E105K	DO229027	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.R101G	SIDM01119	Other Solid Cancers	GDSC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2778
p.R101G	NCI-H727	lung	COSMIC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2778
p.T90S	SIDM01617	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6389
p.T90S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	95:99	Mutation blocking phosphorylation signal	0.6389
p.R144H	SIDM00500	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HERPUD2

UniProt ID: Q9BSE4

Entrez ID: 64224

Protein name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HERPUD2 in