DegronMD

Uniprot ID: Q9BSE4

Source protein: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Source gene: HERPUD2

Class: DEG_SPOP_SBC_1

Location: 95:99

E3 ligase: SPOP

DEGRON score: 0.9326

ASA_SCORE: 100.72

COIL: 0.9362

CONS_SCORE: 0.3062

DSS_SCORE: 0.7576

HELIX: 0.0488

FCONS_SCORE: 0.8331

RIG_SCORE: 0.5308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S103N	TCGA-64-1676	LUAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.2222
p.S103N	DO23629	LUAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.2222
p.R89Q	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.R89Q	TCGA-B5-A11E	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.1667
p.R89Q	DO41644	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.R89Q	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.S98N	TCGA-F7-A624	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	0.7069
p.S98N	DO44440	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	0.7069
p.H104N	TCGA-KQ-A41N	BLCA	TCGA	PKSST	DEG_SPOP_SBC_1	0.1944
p.H104N	DO223588	BLCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1944
p.H104N	DO229022	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1944
p.A108T	DO49225	ALL	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO229016	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO229005	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO229346	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO230659	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO231140	LAML	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO228957	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A108T	DO218840	SKCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.A106T	DO227829	COCA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1389
p.E105K	DO229027	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1667
p.R101G	SIDM01119	Other Solid Cancers	GDSC	PKSST	DEG_SPOP_SBC_1	0.2778
p.R101G	NCI-H727	lung	COSMIC	PKSST	DEG_SPOP_SBC_1	0.2778
p.T90S	SIDM01617	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.6389
p.T90S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons