DegronMD

Uniprot ID: Q7Z3G6

Source protein: Prickle-like protein 2

Source gene: PRICKLE2

Class: DEG_SPOP_SBC_1

Location: 819:823

E3 ligase: SPOP

DEGRON score: 0.7519

ASA_SCORE: 89.34

COIL: 0.8702

CONS_SCORE: 0.379

DSS_SCORE: 0.4586

HELIX: 0.0638

FCONS_SCORE: 1.2016

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T823I	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	0.7078
p.T823I	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	0.7078
p.G817C	TCGA-BR-4184	STAD	TCGA	PKSST	DEG_SPOP_SBC_1	0.2778
p.G817C	DO38328	STAD	ICGC	PKSST	DEG_SPOP_SBC_1	0.2778
p.G817S	TCGA-CN-A6V7	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	0.2778
p.G817S	DO218997	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	0.2778
p.S832C	TCGA-G3-A7M5	LIHC	TCGA	PKSST	DEG_SPOP_SBC_1	0.0833
p.S832C	DO52290	LIHC	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.L818P	DO233044	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	0.3056
p.H831N	DO229029	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.1111
p.L810M	DO229009	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	0.0833
p.N815T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.2222
p.A826T	ACH-000999	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.25
p.A826T	SNU-1040	large_intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	0.25
p.Q814H	ACH-001081	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	0.1944
p.Q814H	HCC2998	large_intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons