DegronMD - Q96AV8(E2F7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G766C	TCGA-44-6144	LUAD	TCGA	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.G766C	DO24190	LUAD	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.P814S	TCGA-46-3768	LUSC	TCGA	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	TCGA-46-3768	LUSC	TCGA	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.P814S	TCGA-86-A4JF	LUAD	TCGA	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	TCGA-86-A4JF	LUAD	TCGA	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.P814S	TCGA-FW-A3R5	SKCM	TCGA	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	TCGA-FW-A3R5	SKCM	TCGA	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.P814S	DO45317	LUAD	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	DO45317	LUAD	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.P814S	DO26466	LUSC	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	DO26466	LUSC	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.P814S	DO37406	SKCM	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.0833
p.P814S	DO37406	SKCM	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1667
p.F483L	TCGA-55-8091	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.F483L	DO229032	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.F483L	DO45334	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.D478H	TCGA-73-4662	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.D478H	DO24790	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.D478H	SIDM01128	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.D478H	ACH-000767	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.D478H	NCI-H526	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.P479H	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.25
p.P479H	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.25
p.V470M	TCGA-A5-A1OF	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.V470M	DO42568	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.A42T	TCGA-A6-2686	COAD	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1944
p.A42T	DO7828	COAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1944
p.R38Q	TCGA-AA-A00N	COAD	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.3056
p.R38Q	DO9876	COAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.3056
p.A800S	TCGA-AP-A059	UCEC	TCGA	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation altering degron motif	0.7588
p.A800S	DO41361	UCEC	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation altering degron motif	0.7588
p.A29T	TCGA-B5-A3FC	UCEC	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2778
p.A29T	DO41871	UCEC	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2778
p.R40G	TCGA-B6-A0RO	BRCA	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.25
p.R40G	DO2764	BRCA	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.25
p.G789R	TCGA-CR-6472	HNSC	TCGA	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1111
p.G789R	DO15870	HNSC	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1111
p.E27Q	TCGA-E5-A2PC	BLCA	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.E27Q	DO702	BLCA	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.G773D	TCGA-EI-6507	READ	TCGA	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2778
p.G773D	DO36675	READ	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2778
p.S807F	TCGA-KO-8408	KICH	TCGA	PKSST	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.7982
p.S807F	DO220562	KICH	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.7982
p.M764I	DO224855	BRCA	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.P810H	DO229015	LICA	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1944
p.P810H	DO229015	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2778
p.S761Y	DO229034	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1667
p.E27A	DO231512	LINC	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.S806P	DO23466	LINC	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.6752
p.T778A	DO230535	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.P484S	DO222743	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.P757L	DO222702	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.0556
p.L775F	DO232066	ORCA	ICGC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.P804S	DO229462	SKCA	ICGC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation altering degron motif	0.6752
p.P804S	DO229462	SKCA	ICGC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.6752
p.D37E	DO38404	STAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.5647
p.S806L	SIDM02021	Esophageal Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.7667
p.A792S	SIDM01169	Ovarian Carcinoma	GDSC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1944
p.A792S	ACH-000885	Ovarian Cancer	CCLE	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1944
p.A792S	TOV-21G	ovary	COSMIC	GPTAVVNPK	DEG_SIAH_1	797:805	Mutation rewiring degron network	0.1944
p.T778I	SIDM00386	Ewing's Sarcoma	GDSC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.T778I	ACH-000391	Bone Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.T778I	MHH-ES-1	bone	COSMIC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.G779E	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.G779E	ACH-000837	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.G779E	NCI-H322M	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.R38P	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENIFVD	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.3056
p.P482A	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.P482A	ACH-000916	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.P482A	NCI-H1573	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.G462E	SIDM00500	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.G462E	ACH-000959	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.S818I	ACH-001613	Leukemia	CCLE	PKSST	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556

Kaplan plot for E2F7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

E2F7

UniProt ID: Q96AV8

Entrez ID: 144455

Protein name: Transcription factor E2F7 (E2F-7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for E2F7 in