DegronMD

Uniprot ID: Q96AV8

Source protein: Transcription factor E2F7

Source gene: E2F7

Class: LIG_APCC_ABBAyCdc20_2

Location: 31:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.611

ASA_SCORE: 80.0571

COIL: 0.6516

CONS_SCORE: 0.3544

DSS_SCORE: 0.5356

HELIX: 0.1997

FCONS_SCORE: 1.0081

RIG_SCORE: 0.7931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A42T	TCGA-A6-2686	COAD	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A42T	DO7828	COAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R38Q	TCGA-AA-A00N	COAD	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R38Q	DO9876	COAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A29T	TCGA-B5-A3FC	UCEC	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A29T	DO41871	UCEC	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R40G	TCGA-B6-A0RO	BRCA	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.R40G	DO2764	BRCA	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.E27Q	TCGA-E5-A2PC	BLCA	TCGA	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E27Q	DO702	BLCA	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E27A	DO231512	LINC	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D37E	DO38404	STAD	ICGC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.5647
p.R38P	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENIFVD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AV8	Transcription factor E2F7	LIG_APCC_ABBAyCdc20_2	31:37	KENIFVD	APC,CDC20,FZR1	0.611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons