DegronMD

Uniprot ID: Q96AV8

Source protein: Transcription factor E2F7

Source gene: E2F7

Class: DEG_SIAH_1

Location: 797:805

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9812

ASA_SCORE: 76.1

COIL: 0.7751

CONS_SCORE: 0.2192

DSS_SCORE: 0.374

HELIX: 0.0189

FCONS_SCORE: 0.973

RIG_SCORE: 0.7226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P814S	TCGA-46-3768	LUSC	TCGA	GPTAVVNPK	DEG_SIAH_1	0.0833
p.P814S	TCGA-86-A4JF	LUAD	TCGA	GPTAVVNPK	DEG_SIAH_1	0.0833
p.P814S	TCGA-FW-A3R5	SKCM	TCGA	GPTAVVNPK	DEG_SIAH_1	0.0833
p.P814S	DO45317	LUAD	ICGC	GPTAVVNPK	DEG_SIAH_1	0.0833
p.P814S	DO26466	LUSC	ICGC	GPTAVVNPK	DEG_SIAH_1	0.0833
p.P814S	DO37406	SKCM	ICGC	GPTAVVNPK	DEG_SIAH_1	0.0833
p.A800S	TCGA-AP-A059	UCEC	TCGA	GPTAVVNPK	DEG_SIAH_1	0.7588
p.A800S	DO41361	UCEC	ICGC	GPTAVVNPK	DEG_SIAH_1	0.7588
p.G789R	TCGA-CR-6472	HNSC	TCGA	GPTAVVNPK	DEG_SIAH_1	0.1111
p.G789R	DO15870	HNSC	ICGC	GPTAVVNPK	DEG_SIAH_1	0.1111
p.P810H	DO229015	LICA	ICGC	GPTAVVNPK	DEG_SIAH_1	0.1944
p.P804S	DO229462	SKCA	ICGC	GPTAVVNPK	DEG_SIAH_1	0.6752
p.A792S	SIDM01169	Ovarian Carcinoma	GDSC	GPTAVVNPK	DEG_SIAH_1	0.1944
p.A792S	ACH-000885	Ovarian Cancer	CCLE	GPTAVVNPK	DEG_SIAH_1	0.1944
p.A792S	TOV-21G	ovary	COSMIC	GPTAVVNPK	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AV8	Transcription factor E2F7	DEG_SIAH_1	797:805	GPTAVVNPK	SIAH1,SIAH2,SIAH3	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons