DegronMD - Q7Z3G6(PRICKLE2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R569Q	TCGA-06-5416	GBM	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.R569Q	DO10880	GBM	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.L593V	TCGA-5L-AAT1	BRCA	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.L593V	DO219594	BRCA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.T823I	TCGA-A5-A0G1	UCEC	TCGA	PKSST	DEG_SPOP_SBC_1	819:823	Mutation altering degron motif	0.7078
p.T823I	DO42472	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation altering degron motif	0.7078
p.D578Y	TCGA-AG-A002	READ	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.7325
p.V583M	TCGA-AX-A1CE	UCEC	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.6097
p.V583M	DO42280	UCEC	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.6097
p.V583G	TCGA-BH-A0HX	BRCA	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.6421
p.V583G	DO5891	BRCA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.6421
p.G817C	TCGA-BR-4184	STAD	TCGA	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.G817C	DO38328	STAD	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.G817S	TCGA-CN-A6V7	HNSC	TCGA	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.G817S	DO218997	HNSC	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.S571A	TCGA-EO-A22R	UCEC	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation blocking phosphorylation signal	0.5833
p.S571A	DO42713	UCEC	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation blocking phosphorylation signal	0.5833
p.S832C	TCGA-G3-A7M5	LIHC	TCGA	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0833
p.S832C	DO52290	LIHC	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0833
p.L818P	DO233044	GACA	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.3056
p.S579Y	DO228971	LICA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation altering degron motif	0.712
p.H831N	DO229029	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.L810M	DO229009	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0833
p.R569G	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.R569G	NCI-H2126	lung	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0833
p.S571Y	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation blocking phosphorylation signal	0.5833
p.S571Y	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation blocking phosphorylation signal	0.5833
p.T590M	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.1667
p.N815T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2222
p.A826T	ACH-000999	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.25
p.A826T	SNU-1040	large intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.25
p.E587K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.25
p.E587K	SNU-1040	large intestine	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.25
p.Q814H	ACH-001081	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1944
p.Q814H	HCC2998	large intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1944
p.G568D	ACH-001550	Skin Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0556
p.G568D	MCC13	skin	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	578:584	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRICKLE2

UniProt ID: Q7Z3G6

Entrez ID: 166336

Protein name: Prickle-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRICKLE2 in