DegronMD

Uniprot ID: Q7Z3G6

Source protein: Prickle-like protein 2

Source gene: PRICKLE2

Class: DEG_SCF_TRCP1_1

Location: 578:584

E3 ligase: BTRC

DEGRON score: 0.9995

ASA_SCORE: 75.6571

COIL: 0.8533

CONS_SCORE: 0.3666

DSS_SCORE: 0.5465

HELIX: 0.1241

FCONS_SCORE: 1.0145

RIG_SCORE: 0.6544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R569Q	TCGA-06-5416	GBM	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.R569Q	DO10880	GBM	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.L593V	TCGA-5L-AAT1	BRCA	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.L593V	DO219594	BRCA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.D578Y	TCGA-AG-A002	READ	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.7325
p.V583M	TCGA-AX-A1CE	UCEC	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.6097
p.V583M	DO42280	UCEC	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.6097
p.V583G	TCGA-BH-A0HX	BRCA	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.6421
p.V583G	DO5891	BRCA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.6421
p.S571A	TCGA-EO-A22R	UCEC	TCGA	DSGMNVS	DEG_SCF_TRCP1_1	0.5833
p.S571A	DO42713	UCEC	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.5833
p.S579Y	DO228971	LICA	ICGC	DSGMNVS	DEG_SCF_TRCP1_1	0.712
p.R569G	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.R569G	NCI-H2126	lung	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	0.0833
p.S571Y	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGMNVS	DEG_SCF_TRCP1_1	0.5833
p.S571Y	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	0.5833
p.T590M	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	0.1667
p.E587K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	0.25
p.E587K	SNU-1040	large_intestine	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	0.25
p.G568D	ACH-001550	Skin Cancer	CCLE	DSGMNVS	DEG_SCF_TRCP1_1	0.0556
p.G568D	MCC13	skin	COSMIC	DSGMNVS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3G6	Prickle-like protein 2	DEG_SCF_TRCP1_1	578:584	DSGMNVS	BTRC	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons