DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 2472:2476

E3 ligase: SPOP

DEGRON score: 0.8841

ASA_SCORE: 99.16

COIL: 0.8768

CONS_SCORE: 0.3113

DSS_SCORE: 0.6771

HELIX: 0.02

FCONS_SCORE: 1.1637

RIG_SCORE: 0.5849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2462C	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.0556
p.T2476A	SIDM01045	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.7139
p.P2464T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.1111
p.S2478Y	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.2778
p.R2467I	SIDM01588	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2472:2476	PKSST	SPOP	0.8841	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	853:857	PKSST	SPOP	0.9891	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1451:1455	PKSST	SPOP	0.9939	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	804:808	PKSST	SPOP	0.9603	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	95:99	PKSST	SPOP	0.9326	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	420:424	PKSST	SPOP	0.8629	More...
Q7Z3G6	Prickle-like protein 2	DEG_SPOP_SBC_1	819:823	PKSST	SPOP	0.7519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons