DegronMD - Q8IZD2(KMT2E)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1204G	TCGA-06-5416	GBM	TCGA	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation altering degron motif	0.7198
p.D1204G	DO10880	GBM	ICGC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation altering degron motif	0.7198
p.P1591A	TCGA-24-1434	OV	TCGA	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation altering degron motif	0.6392
p.M906L	TCGA-29-1711	OV	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1944
p.M906L	DO30630	OV	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1944
p.Y66C	TCGA-2G-AAGI	TGCT	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2222
p.P1549S	TCGA-39-5031	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.2778
p.Y931C	TCGA-42-2590	OV	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1111
p.Y931C	DO30670	OV	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1111
p.V937A	TCGA-5M-AAT6	COAD	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.2778
p.V937A	DO223703	COAD	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.2778
p.A1503V	TCGA-60-2698	LUSC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.0833
p.S909C	TCGA-86-6851	LUAD	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1111
p.S909C	DO23798	LUAD	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1111
p.C1199R	TCGA-A3-3376	KIRC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.25
p.C1199R	DO20555	KIRC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.25
p.P1549H	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.2778
p.S953Y	TCGA-A5-A1OF	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1111
p.S953Y	DO42568	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1111
p.P1550S	TCGA-A5-A2K5	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.3056
p.G1198D	TCGA-AA-3947	COAD	TCGA	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.G1198D	DO8192	COAD	ICGC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.G1198D	SIDM01006	Plasma Cell Myeloma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.G1198D	ACH-000193	Myeloma	CCLE	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.G1198D	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.2222
p.S952Y	TCGA-AG-A002	READ	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1389
p.S952Y	TCGA-AX-A0J0	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1389
p.S952Y	DO41133	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1389
p.R1276Q	TCGA-AG-A002	READ	TCGA	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2222
p.R1276Q	TCGA-AX-A2HC	UCEC	TCGA	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2222
p.R1276Q	DO41572	UCEC	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2222
p.N950T	TCGA-AJ-A5DW	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1944
p.N950T	DO50075	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1944
p.S909F	TCGA-AP-A0LM	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1111
p.S909F	DO43306	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1111
p.D902N	TCGA-AP-A1E0	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.D902N	TCGA-AZ-4315	COAD	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.D902N	TCGA-B5-A11E	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.D902N	DO8842	COAD	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.D902N	DO43154	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.D902N	DO41644	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.3056
p.T1490K	TCGA-AX-A3G3	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation altering degron motif	0.7306
p.D1278H	TCGA-AY-6196	COAD	TCGA	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2778
p.D1278H	DO10300	COAD	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2778
p.F1499L	TCGA-B5-A1MR	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1944
p.R1493Q	TCGA-B6-A0IK	BRCA	TCGA	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation altering degron motif	0.6218
p.V1604L	TCGA-CG-4437	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.0833
p.T1807A	TCGA-CG-4442	STAD	TCGA	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation altering degron motif	0.6028
p.L1590V	TCGA-D1-A16X	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.3056
p.A1502T	TCGA-D1-A1NS	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1111
p.S952F	TCGA-D3-A3MU	SKCM	TCGA	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1389
p.S952F	DO47337	SKCM	ICGC	PGTPGNT	DEG_SCF_FBW7_1	939:945	Mutation rewiring degron network	0.1389
p.T1455M	TCGA-D7-A6EY	STAD	TCGA	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7423
p.T901A	TCGA-DD-A3A2	LIHC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation altering degron motif	0.7139
p.T901A	DO44881	LIHC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation altering degron motif	0.7139
p.D1197A	TCGA-DD-AACV	LIHC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1944
p.D1197A	DO219565	LIHC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1944
p.P74L	TCGA-DY-A0XA	READ	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7582
p.P74L	DO37026	READ	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7582
p.H1814Y	TCGA-E7-A6MD	BLCA	TCGA	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.1944
p.N87S	TCGA-E9-A5UO	BRCA	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.0556
p.N87S	DO44105	BRCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.0556
p.N65H	TCGA-EI-6917	READ	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1944
p.N65H	DO36881	READ	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1944
p.Q1588E	TCGA-EK-A3GK	CESC	TCGA	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.25
p.P1815H	TCGA-FS-A1ZN	SKCM	TCGA	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.1667
p.S1563C	TCGA-GC-A6I3	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.1111
p.R69C	TCGA-H7-A76A	HNSC	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.3056
p.R69C	DO52088	HNSC	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.3056
p.A76T	TCGA-HU-A4GX	STAD	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6028
p.A76T	DO47757	STAD	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6028
p.A62V	TCGA-L5-A8NU	ESCA	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1111
p.D1210G	TCGA-NC-A5HG	LUSC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.25
p.D1210G	DO45448	LUSC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.25
p.Q1558E	TCGA-XF-A8HE	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.25
p.Q1454K	DO48362	BLCA	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.6944
p.R1451Q	DO1902	BRCA	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7329
p.Q1801K	DO1559	BRCA	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.2778
p.Q1794H	DO222941	BTCA	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.0833
p.Q1794H	DO42793	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.0833
p.T1293M	DO222973	BTCA	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1111
p.Y61C	DO229383	BTCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.0833
p.Q1546E	DO49964	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.1944
p.P1453A	DO6494	CLLE	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7503
p.P908T	DO230326	COCA	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1389
p.Q1601H	DO228948	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.1667
p.E1452D	DO229026	LICA	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.6758
p.P898L	DO229050	LICA	ICGC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation altering degron motif	0.7582
p.A1461V	DO26469	LUSC	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1667
p.P1288A	DO52025	LUSC	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.25
p.VL82VF	DO222494	MELA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0
p.L1272F	DO222595	MELA	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1111
p.P1549A	DO28014	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.2778
p.D1282G	DO228168	PBCA	ICGC	DSGGES	DEG_SCF_TRCP1_1	1280:1285	Mutation altering degron motif	0.7198
p.P71S	DO218855	SKCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.5641
p.V1562L	DO38467	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.1389
p.A1582V	DO47823	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.0833
p.Q1495H	DO219771	UCEC	ICGC	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.3056
p.A1460T	DO42193	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1944
p.A1800V	DO42312	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.25
p.T1448K	DO41050	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.25
p.T1488A	DO41752	UCEC	ICGC	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation altering degron motif	0.7139
p.F1457L	DO41758	UCEC	ICGC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.2778
p.V1599I	DO41999	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.2222
p.L1548V	DO41799	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation rewiring degron network	0.25
p.T1552I	DO41199	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation altering degron motif	0.7078
p.I1795M	DO41337	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.1111
p.G1793E	DO42665	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.0556
p.V1583L	DO230445	UTCA	ICGC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation rewiring degron network	0.1111
p.P908S	SIDM00131	Glioma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1389
p.P908S	SIDM00942	Oral Cavity Carcinoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1389
p.P908S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.1389
p.P1591T	SIDM00798	Rhabdomyosarcoma	GDSC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation altering degron motif	0.7031
p.P1591T	ACH-000201	Rhabdoid	CCLE	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation altering degron motif	0.7031
p.P1591T	ACH-001212	Rhabdoid	CCLE	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation altering degron motif	0.7031
p.P1591T	A204	soft tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	1591:1595	Mutation altering degron motif	0.7031
p.S1554P	SIDM01722	Non-Cancerous	GDSC	PPSSS	DEG_SPOP_SBC_1	1551:1555	Mutation altering degron motif	0.6752
p.N1195S	SIDM00197	Ewing's Sarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1389
p.N1195S	SIDM00836	Colorectal Carcinoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1389
p.N1195S	SIDM00044	Head and Neck Carcinoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1389
p.N1195S	SIDM01746	Osteosarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1389
p.N1195S	SIDM01316	Ewing's Sarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	1202:1207	Mutation rewiring degron network	0.1389
p.G1810E	SIDM00974	Melanoma	GDSC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.3056
p.G1810E	ACH-002207	Skin Cancer	CCLE	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.3056
p.G1810E	WM35	skin	COSMIC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.3056
p.P1443L	SIDM00596	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1111
p.P1443L	ACH-000941	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1111
p.P1443L	ACH-000954	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1111
p.P1443L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1111
p.P1443L	HEC-1	endometrium	COSMIC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.1111
p.P905S	SIDM00049	Colorectal Carcinoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.2222
p.P905S	ACH-002233	Colon/Colorectal Cancer	CCLE	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.2222
p.P905S	DIFI	large intestine	COSMIC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.2222
p.P905A	SIDM01107	Melanoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.2222
p.P905A	SK-MEL-1	skin	COSMIC	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation rewiring degron network	0.2222
p.P72L	SIDM00217	Colorectal Carcinoma	GDSC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6471
p.P72L	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6471
p.P72L	SNU-1040	large intestine	COSMIC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6471
p.S1454F	SIDM00217	Colorectal Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7982
p.S1454F	ACH-000999	Colon/Colorectal Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7982
p.S1454F	SNU-1040	large intestine	COSMIC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation altering degron motif	0.7982
p.S1483L	SIDM01131	Small Cell Lung Carcinoma	GDSC	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1944
p.S1483L	ACH-000355	Lung Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1944
p.S1483L	NCI-H82	lung	COSMIC	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1944
p.P1459S	SIDM01608	Endometrial Carcinoma	GDSC	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.2222
p.P1459S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PKSST	DEG_SPOP_SBC_1	1451:1455	Mutation rewiring degron network	0.2222
p.F1811L	SIDM01619	Endometrial Carcinoma	GDSC	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.2778
p.F1811L	ACH-000984	Endometrial/Uterine Cancer	CCLE	IPTPTAS	DEG_SCF_FBW7_1	1803:1809	Mutation rewiring degron network	0.2778
p.H1481R	ACH-000143	Lung Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation rewiring degron network	0.1389
p.T1490I	ACH-001197	Lymphoma	CCLE	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation altering degron motif	0.7078
p.T901S	ACH-001395	Breast Cancer	CCLE	PYATPTHT	DEG_SCF_FBW7_1	894:901	Mutation altering degron motif	0.6005
p.G1489E	ACH-001664	Gastric Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	1488:1494	Mutation altering degron motif	0.6087
p.R85M	G-MEL	skin	COSMIC	PPPTPPAS	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2E

UniProt ID: Q8IZD2

Entrez ID: 55904

Protein name: Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KMT2E in