DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_Kelch_Keap1_1

Location: 1202:1207

E3 ligase: KEAP1

DEGRON score: 0.9226

ASA_SCORE: 95.5333

COIL: 0.9215

CONS_SCORE: 0.3133

DSS_SCORE: 0.6461

HELIX: 0.055

FCONS_SCORE: 0.9354

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1204G	TCGA-06-5416	GBM	TCGA	SNDNGE	DEG_Kelch_Keap1_1	0.7198
p.D1204G	DO10880	GBM	ICGC	SNDNGE	DEG_Kelch_Keap1_1	0.7198
p.C1199R	TCGA-A3-3376	KIRC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	0.25
p.C1199R	DO20555	KIRC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	0.25
p.G1198D	TCGA-AA-3947	COAD	TCGA	SNDNGE	DEG_Kelch_Keap1_1	0.2222
p.G1198D	DO8192	COAD	ICGC	SNDNGE	DEG_Kelch_Keap1_1	0.2222
p.G1198D	SIDM01006	Plasma Cell Myeloma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.2222
p.G1198D	ACH-000193	Myeloma	CCLE	SNDNGE	DEG_Kelch_Keap1_1	0.2222
p.G1198D	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	SNDNGE	DEG_Kelch_Keap1_1	0.2222
p.D1197A	TCGA-DD-AACV	LIHC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	0.1944
p.D1197A	DO219565	LIHC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	0.1944
p.D1210G	TCGA-NC-A5HG	LUSC	TCGA	SNDNGE	DEG_Kelch_Keap1_1	0.25
p.D1210G	DO45448	LUSC	ICGC	SNDNGE	DEG_Kelch_Keap1_1	0.25
p.N1195S	SIDM00197	Ewing's Sarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.1389
p.N1195S	SIDM00836	Colorectal Carcinoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.1389
p.N1195S	SIDM00044	Head and Neck Carcinoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.1389
p.N1195S	SIDM01746	Osteosarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.1389
p.N1195S	SIDM01316	Ewing's Sarcoma	GDSC	SNDNGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_Kelch_Keap1_1	1202:1207	SNDNGE	KEAP1	0.9226	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons