DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_FBW7_1

Location: 939:945

E3 ligase: FBXW7

DEGRON score: 0.9863

ASA_SCORE: 82.6571

COIL: 0.9463

CONS_SCORE: 0.3646

DSS_SCORE: 0.5967

HELIX: 0.0347

FCONS_SCORE: 1.0201

RIG_SCORE: 0.5968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y931C	TCGA-42-2590	OV	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1111
p.Y931C	DO30670	OV	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.1111
p.V937A	TCGA-5M-AAT6	COAD	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.2778
p.V937A	DO223703	COAD	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.2778
p.S953Y	TCGA-A5-A1OF	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1111
p.S953Y	DO42568	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.1111
p.S952Y	TCGA-AG-A002	READ	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1389
p.S952Y	TCGA-AX-A0J0	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1389
p.S952Y	DO41133	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.1389
p.N950T	TCGA-AJ-A5DW	UCEC	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1944
p.N950T	DO50075	UCEC	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.1944
p.S952F	TCGA-D3-A3MU	SKCM	TCGA	PGTPGNT	DEG_SCF_FBW7_1	0.1389
p.S952F	DO47337	SKCM	ICGC	PGTPGNT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_FBW7_1	939:945	PGTPGNT	FBXW7	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons