DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_FBW7_1

Location: 1803:1809

E3 ligase: FBXW7

DEGRON score: 0.9495

ASA_SCORE: 84.2857

COIL: 0.948

CONS_SCORE: 0.3464

DSS_SCORE: 0.6909

HELIX: 0.0239

FCONS_SCORE: 1.0435

RIG_SCORE: 0.6056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1807A	TCGA-CG-4442	STAD	TCGA	IPTPTAS	DEG_SCF_FBW7_1	0.6028
p.H1814Y	TCGA-E7-A6MD	BLCA	TCGA	IPTPTAS	DEG_SCF_FBW7_1	0.1944
p.P1815H	TCGA-FS-A1ZN	SKCM	TCGA	IPTPTAS	DEG_SCF_FBW7_1	0.1667
p.Q1801K	DO1559	BRCA	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.2778
p.Q1794H	DO222941	BTCA	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.0833
p.Q1794H	DO42793	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.0833
p.A1800V	DO42312	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.25
p.I1795M	DO41337	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.1111
p.G1793E	DO42665	UCEC	ICGC	IPTPTAS	DEG_SCF_FBW7_1	0.0556
p.G1810E	SIDM00974	Melanoma	GDSC	IPTPTAS	DEG_SCF_FBW7_1	0.3056
p.G1810E	ACH-002207	Skin Cancer	CCLE	IPTPTAS	DEG_SCF_FBW7_1	0.3056
p.G1810E	WM35	skin	COSMIC	IPTPTAS	DEG_SCF_FBW7_1	0.3056
p.F1811L	SIDM01619	Endometrial Carcinoma	GDSC	IPTPTAS	DEG_SCF_FBW7_1	0.2778
p.F1811L	ACH-000984	Endometrial/Uterine Cancer	CCLE	IPTPTAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_FBW7_1	1803:1809	IPTPTAS	FBXW7	0.9495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons