DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_FBW7_1

Location: 894:901

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 98.9125

COIL: 0.9526

CONS_SCORE: 0.3738

DSS_SCORE: 0.6638

HELIX: 0.0214

FCONS_SCORE: 1.0827

RIG_SCORE: 0.6439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M906L	TCGA-29-1711	OV	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.1944
p.M906L	DO30630	OV	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.1944
p.S909C	TCGA-86-6851	LUAD	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.1111
p.S909C	DO23798	LUAD	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.1111
p.S909F	TCGA-AP-A0LM	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.1111
p.S909F	DO43306	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.1111
p.D902N	TCGA-AP-A1E0	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.D902N	TCGA-AZ-4315	COAD	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.D902N	TCGA-B5-A11E	UCEC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.D902N	DO8842	COAD	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.D902N	DO43154	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.D902N	DO41644	UCEC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.3056
p.T901A	TCGA-DD-A3A2	LIHC	TCGA	PYATPTHT	DEG_SCF_FBW7_1	0.7139
p.T901A	DO44881	LIHC	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.7139
p.P908T	DO230326	COCA	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.1389
p.P898L	DO229050	LICA	ICGC	PYATPTHT	DEG_SCF_FBW7_1	0.7582
p.P908S	SIDM00131	Glioma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	0.1389
p.P908S	SIDM00942	Oral Cavity Carcinoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	0.1389
p.P908S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	0.1389
p.P905S	SIDM00049	Colorectal Carcinoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	0.2222
p.P905S	ACH-002233	Colon/Colorectal Cancer	CCLE	PYATPTHT	DEG_SCF_FBW7_1	0.2222
p.P905S	DIFI	large_intestine	COSMIC	PYATPTHT	DEG_SCF_FBW7_1	0.2222
p.P905A	SIDM01107	Melanoma	GDSC	PYATPTHT	DEG_SCF_FBW7_1	0.2222
p.P905A	SK-MEL-1	skin	COSMIC	PYATPTHT	DEG_SCF_FBW7_1	0.2222
p.T901S	ACH-001395	Breast Cancer	CCLE	PYATPTHT	DEG_SCF_FBW7_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_FBW7_1	894:901	PYATPTHT	FBXW7	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons