DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SPOP_SBC_1

Location: 1591:1595

E3 ligase: SPOP

DEGRON score: 0.9888

ASA_SCORE: 81.8

COIL: 0.9692

CONS_SCORE: 0.3418

DSS_SCORE: 0.7198

HELIX: 0.0178

FCONS_SCORE: 1.0327

RIG_SCORE: 0.6162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1591A	TCGA-24-1434	OV	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6392
p.V1604L	TCGA-CG-4437	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.L1590V	TCGA-D1-A16X	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.3056
p.Q1588E	TCGA-EK-A3GK	CESC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.25
p.Q1601H	DO228948	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.A1582V	DO47823	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.V1599I	DO41999	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.V1583L	DO230445	UTCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.P1591T	SIDM00798	Rhabdomyosarcoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7031
p.P1591T	ACH-000201	Rhabdoid	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7031
p.P1591T	ACH-001212	Rhabdoid	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7031
p.P1591T	A204	soft_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons