DegronMD

Uniprot ID: Q9UKU6

Source protein: Thyrotropin-releasing hormone-degrading ectoenzyme

Source gene: TRHDE

Class: DEG_SPOP_SBC_1

Location: 117:121

E3 ligase: SPOP

DEGRON score: 0.9471

ASA_SCORE: 81.44

COIL: 0.909

CONS_SCORE: 0.3817

DSS_SCORE: 0.855

HELIX: 0.0186

FCONS_SCORE: 0.9995

RIG_SCORE: 0.5465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T120M	TCGA-14-0871	GBM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7423
p.T120M	DO12640	GBM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7423
p.R130L	TCGA-BF-A1Q0	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.R130L	DO47374	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.E128K	TCGA-EB-A5UL	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E128K	DO47601	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E129Q	TCGA-ZF-AA51	BLCA	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1111
p.E129Q	DO219093	BLCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.A111V	SIDM01305	Colorectal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.S121L	SIDM00353	Other Sarcomas	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7667
p.S121L	ACH-000505	Sarcoma	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7667
p.S121L	RKN	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7667
p.V114G	ACH-000174	Thyroid Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-000347	Pancreatic Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-000708	Colon/Colorectal Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-000979	Prostate Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-002102	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-002242	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-002267	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25
p.V114G	ACH-002295	Head and Neck Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons