DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: DEG_SPOP_SBC_1

Location: 434:438

E3 ligase: SPOP

DEGRON score: 0.9249

ASA_SCORE: 74.86

COIL: 0.9092

CONS_SCORE: 0.3352

DSS_SCORE: 0.8118

HELIX: 0.048

FCONS_SCORE: 0.9711

RIG_SCORE: 0.4636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G433S	TCGA-2Y-A9GU	LIHC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.3056
p.G433S	TCGA-ER-A42K	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.3056
p.G427E	TCGA-AP-A1DV	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.S442F	TCGA-BF-A9VF	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.P434L	TCGA-ER-A2NC	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7582
p.S424L	TCGA-FS-A4FC	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0556
p.G435E	TCGA-J4-A67M	PRAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6087
p.T437N	TCGA-L4-A4E5	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7055
p.S428L	DO228452	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.S428L	DO37762	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.P438L	DO233252	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7582
p.P438L	DO47318	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7582
p.G437S	DO219507	LIHC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6993
p.G437S	DO51252	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6993
p.T441N	DO24320	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.25
p.V426L	DO27532	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.T425I	DO228338	MALY	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.T425I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.G435D	DO222363	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6087
p.G439E	DO48658	PRAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.G431E	DO43186	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.25
p.S430L	SIDM02014	Esophageal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.A444V	SIDM00596	Endometrial Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.A444V	HEC-1	endometrium	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.R445Q	SIDM01526	Mesothelioma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.L424I	COR-L321	NS	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons