DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PGTTS
Uniprot ID:
P11831
Source protein:
Serum response factor
Source gene:
SRF
Class:
DEG_SPOP_SBC_1
Location:
273:277
E3 ligase:
SPOP
DEGRON score:
0.9973
ASA_SCORE:
69.36
COIL:
0.9106
CONS_SCORE:
0.3446
DSS_SCORE:
0.5218
HELIX:
0.0346
FCONS_SCORE:
1.1004
RIG_SCORE:
0.7012
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A268E
DO227982
COCA
ICGC
PGTTS
DEG_SPOP_SBC_1
0.1944
p.T268I
SIDM01278
Colorectal Carcinoma
GDSC
PGTTS
DEG_SPOP_SBC_1
0.1944
Drug responses associated with SRF mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NDV4
Transmembrane protein 8B
DEG_SPOP_SBC_1
26:30
PGTTS
SPOP
0.948
More...
P11831
Serum response factor
DEG_SPOP_SBC_1
273:277
PGTTS
SPOP
0.9973
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2832:2836
PGTTS
SPOP
0.6952
More...
Q5TBA9
Protein furry homolog
DEG_SPOP_SBC_1
1963:1967
PGTTS
SPOP
0.8986
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1426:1430
PGTTS
SPOP
0.5627
More...
Q8IZD2
Inactive histone-lysine N-methyltransferase 2E
DEG_SPOP_SBC_1
1591:1595
PGTTS
SPOP
0.9888
More...
Q8N0Y2
Zinc finger protein 444
DEG_SPOP_SBC_1
176:180
PGTTS
SPOP
0.5828
More...
Q8NFW1
Collagen alpha-1
DEG_SPOP_SBC_1
851:855
PGTTS
SPOP
0.8684
More...
Q9BQI5
SH3-containing GRB2-like protein 3-interacting protein 1
DEG_SPOP_SBC_1
434:438
PGTTS
SPOP
0.9249
More...
Q9UGL1
Lysine-specific demethylase 5B
DEG_SPOP_SBC_1
1308:1312
PGTTS
SPOP
0.888
More...
Q9UKU6
Thyrotropin-releasing hormone-degrading ectoenzyme
DEG_SPOP_SBC_1
117:121
PGTTS
SPOP
0.9471
More...
Q9ULT8
E3 ubiquitin-protein ligase HECTD1
DEG_SPOP_SBC_1
1602:1606
PGTTS
SPOP
0.9335
More...
Q9UQ35
Serine/arginine repetitive matrix protein 2
DEG_SPOP_SBC_1
313:317
PGTTS
SPOP
0.9196
More...
Q9UQR0
Sex comb on midleg-like protein 2
DEG_SPOP_SBC_1
578:582
PGTTS
SPOP
0.9989
More...
Q96DN6
Methyl-CpG-binding domain protein 6
DEG_SPOP_SBC_1
462:466
PGTTS
SPOP
0.9976
More...