DegronMD

Uniprot ID: Q8NFW1

Source protein: Collagen alpha-1

Source gene: COL22A1

Class: DEG_SPOP_SBC_1

Location: 851:855

E3 ligase: SPOP

DEGRON score: 0.8684

ASA_SCORE: 64.88

COIL: 0.9062

CONS_SCORE: 0.4482

DSS_SCORE: 0.8463

HELIX: 0.0348

FCONS_SCORE: 0.9017

RIG_SCORE: 0.5818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T854I	TCGA-17-Z042	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7078
p.P864H	TCGA-55-7574	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.P864H	DO229006	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.P864H	DO23986	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.S855F	TCGA-A2-A0CR	BRCA	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7982
p.S855F	DO44163	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7982
p.R862W	TCGA-AA-3861	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.R862W	DO9562	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.R862W	DO233898	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.P847S	TCGA-D3-A8GM	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.P847S	TCGA-R6-A6XQ	ESCA	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.P847S	DO50288	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.L850V	TCGA-D7-6822	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.3056
p.L850V	DO38423	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.P851S	TCGA-D9-A1JX	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6752
p.P851S	DO37711	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6752
p.M863I	TCGA-OR-A5KB	ACC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1111
p.P864L	DO233276	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.P844S	DO231724	LINC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E841K	DO23498	LINC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.A842T	DO231204	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.T853N	DO32819	PACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7055
p.T853N	SIDM01136	Pancreatic Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7055
p.T853N	PANC-08-13	pancreas	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7055
p.S855Y	SIDM01156	Small Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.712
p.S855Y	ACH-000890	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.712
p.R862L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.R862L	ACH-000665	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.1389
p.R862L	SK-MES-1	lung	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.G846D	ACH-000512	Myeloma	CCLE	PGTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTS

Degron related mutations and impact score

Drug responses associated with COL22A1 mutations

All proteins holding degron of PGTTS