DegronMD - Q9ULT8(HECTD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1626A	TCGA-85-8072	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.T1626A	DO27667	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.K1403N	TCGA-86-8673	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation substituting flanking lysine	0.2222
p.K1403N	DO26260	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation substituting flanking lysine	0.2222
p.T1626P	TCGA-A5-A0G2	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.T1626P	DO41235	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.V1435I	TCGA-A5-A0G2	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.1944
p.V1435I	DO233261	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.1944
p.V1435I	DO41235	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.1944
p.S1398N	TCGA-A5-A0G2	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.S1398N	DO41235	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.P743R	TCGA-A8-A08P	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2778
p.P743R	DO5298	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2778
p.T1800A	TCGA-AA-3715	COAD	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.825
p.T1800A	DO8018	COAD	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.825
p.D1370Y	TCGA-AB-2860	LAML	TCGA	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1667
p.D1370Y	DO21057	LAML	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1667
p.S1380I	TCGA-AG-A002	READ	TCGA	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation altering degron motif	0.7341
p.R1471C	TCGA-AN-A046	BRCA	TCGA	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719
p.R1471C	DO1285	BRCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719
p.R1471C	DO227999	COCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719
p.R1471C	DO46352	OV	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719
p.D1339N	TCGA-AX-A1CE	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0833
p.D1339N	DO42280	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0833
p.S1361N	TCGA-AX-A2HC	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0833
p.S1361N	DO41572	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0833
p.A1624T	TCGA-AX-A2HD	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1944
p.A1624T	DO42608	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1944
p.G1465D	TCGA-AZ-4315	COAD	TCGA	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.1944
p.G1465D	DO8842	COAD	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.1944
p.E1804D	TCGA-B5-A1MR	UCEC	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.6758
p.E1804D	DO41758	UCEC	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.6758
p.T1357A	TCGA-B5-A3FA	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation blocking phosphorylation signal	0.6389
p.T1357A	DO224595	LAML	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation blocking phosphorylation signal	0.6389
p.T1357A	DO52402	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation blocking phosphorylation signal	0.6389
p.T1455M	TCGA-BG-A220	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1944
p.T1455M	DO41784	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.1944
p.G1400V	TCGA-BQ-7058	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400V	DO20788	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.L1599F	TCGA-C5-A7UH	CESC	TCGA	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation altering degron motif	0.6981
p.L1599F	DO49891	CESC	ICGC	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation altering degron motif	0.6981
p.R730K	TCGA-C5-A8XK	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1389
p.R730K	DO49904	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1389
p.T1623A	TCGA-CG-5721	STAD	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.2222
p.T1623A	DO38192	STAD	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.2222
p.S1629L	TCGA-CK-4951	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.0556
p.S1629L	DO10582	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.0556
p.R258C	TCGA-CN-4738	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1944
p.R258C	DO14214	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1944
p.E1794Q	TCGA-CQ-5334	HNSC	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.25
p.E1794Q	DO16053	HNSC	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.25
p.G1525V	TCGA-D3-A1Q3	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.2778
p.G1525V	DO47509	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.2778
p.P1796Q	TCGA-D3-A2J6	SKCM	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.3056
p.P1796Q	DO37901	SKCM	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.3056
p.G1592C	TCGA-D3-A3CE	SKCM	TCGA	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation rewiring degron network	0.1389
p.G1592C	TCGA-D3-A3CE	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	1602:1606	Mutation rewiring degron network	0.0556
p.G1592C	DO37405	SKCM	ICGC	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation rewiring degron network	0.1389
p.G1592C	DO37405	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	1602:1606	Mutation rewiring degron network	0.0556
p.P1597L	TCGA-EE-A2GO	SKCM	TCGA	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation rewiring degron network	0.2778
p.P1597L	TCGA-EE-A2GO	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	1602:1606	Mutation rewiring degron network	0.1944
p.P1597L	DO37823	SKCM	ICGC	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation rewiring degron network	0.2778
p.P1597L	DO37823	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	1602:1606	Mutation rewiring degron network	0.1944
p.E1810K	TCGA-EI-6917	READ	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.1667
p.E1810K	DO222769	COCA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.1667
p.E1810K	DO36881	READ	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.1667
p.Q1437K	TCGA-ER-A19B	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.25
p.Q1437K	TCGA-ER-A19B	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.0833
p.Q1437K	DO47491	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.25
p.Q1437K	DO47491	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.0833
p.P1466S	TCGA-ER-A19G	SKCM	TCGA	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.2222
p.P1466S	DO47284	SKCM	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.2222
p.S1385R	TCGA-GI-A2C8	BRCA	TCGA	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation blocking phosphorylation signal	0.6389
p.S1385R	TCGA-GI-A2C8	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation blocking phosphorylation signal	0.6111
p.S1385R	DO5992	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation blocking phosphorylation signal	0.6389
p.S1385R	DO5992	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation blocking phosphorylation signal	0.6111
p.T1626I	TCGA-IB-7651	PAAD	TCGA	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.T1626I	DO46657	PAAD	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.1389
p.S1529R	TCGA-IB-7651	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.7427
p.S1529R	DO46657	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.7427
p.V735A	TCGA-IB-7651	PAAD	TCGA	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2778
p.V735A	DO46657	PAAD	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2778
p.M1528V	TCGA-K4-A6MB	BLCA	TCGA	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.6097
p.M1528V	DO44077	BLCA	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.6097
p.V1435D	TCGA-OR-A5J2	ACC	TCGA	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.1944
p.E1461K	TCGA-XF-A9SM	BLCA	TCGA	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.0833
p.E1461K	DO223597	BLCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.0833
p.T1791A	DO50531	BOCA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.1667
p.S1519N	DO225331	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation rewiring degron network	0.1111
p.S1519N	DO225331	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.1111
p.A1376T	DO227844	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation altering degron motif	0.7139
p.E1541D	DO222798	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.0556
p.T1404M	DO233634	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.0833
p.R730T	DO233728	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1389
p.T1472I	DO233871	GACA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.8189
p.S740L	DO228946	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7667
p.S1362R	DO228952	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0556
p.Q1788K	DO228974	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.0833
p.S1384R	DO228976	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation blocking phosphorylation signal	0.6667
p.S1384R	DO228976	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation blocking phosphorylation signal	0.5833
p.S1384R	DO229032	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation blocking phosphorylation signal	0.6667
p.S1384R	DO229032	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation blocking phosphorylation signal	0.5833
p.Q1358K	DO228976	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.1667
p.P750H	DO228976	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.0833
p.P1797T	DO228971	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.7031
p.Q1789K	DO228986	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.1111
p.Q742K	DO229029	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.3056
p.P1348H	DO229029	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation altering degron motif	0.7694
p.D1339E	DO229027	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.0833
p.N1367K	DO229032	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.0833
p.N1367K	DO229045	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.0833
p.P737Q	DO229009	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7035
p.S1395R	DO229009	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation altering degron motif	0.7427
p.S1444C	DO50818	LIRI	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation altering degron motif	0.7541
p.A1374T	DO221126	MALY	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.2778
p.A1344T	DO232042	ORCA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation rewiring degron network	0.2222
p.A1453T	DO232224	PBCA	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.0833
p.A1453T	DO232224	PBCA	ICGC	ASTST	DEG_SPOP_SBC_1	1446:1450	Mutation rewiring degron network	0.25
p.R1471H	DO229569	PRAD	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.7133
p.S1373Y	DO51105	PRAD	ICGC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation blocking phosphorylation signal	0.6944
p.I1795L	DO47162	RECA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.2778
p.S1520F	DO228014	SKCA	ICGC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation blocking phosphorylation signal	0.5278
p.S1520F	DO228014	SKCA	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation blocking phosphorylation signal	0.5833
p.S1613Y	DO229459	SKCA	ICGC	LTTPGTT	DEG_SCF_FBW7_1	1599:1605	Mutation rewiring degron network	0.1111
p.S1613Y	DO229459	SKCA	ICGC	PGTTS	DEG_SPOP_SBC_1	1602:1606	Mutation rewiring degron network	0.1389
p.S1613Y	DO229459	SKCA	ICGC	VTSSS	DEG_SPOP_SBC_1	1615:1619	Mutation rewiring degron network	0.2778
p.G1400A	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	ACH-001067	Brain Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	DND-41	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.G1400A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.1944
p.S1511L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.S1511L	ACH-000824	Esophageal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.S1511L	KYSE-510	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.T1800S	SIDM01045	Endometrial Carcinoma	GDSC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.T1800S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.T1800S	EN	endometrium	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.Q275H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1111
p.Q275H	ACH-000951	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1111
p.Q275H	NCI-H2342	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1111
p.V1388L	SIDM00220	Ovarian Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.V1388L	SIDM00220	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.V1388L	ACH-000962	Ovarian Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.V1388L	ACH-000962	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.V1388L	ACH-001145	Ovarian Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.V1388L	ACH-001145	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.V1388L	OC-314	ovary	COSMIC	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.V1388L	OC-314	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.25
p.A1524S	SIDM01318	Hepatocellular Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.25
p.A1524S	ACH-001318	Liver Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.25
p.G257S	SIDM01608	Endometrial Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1667
p.G257S	ACH-000990	Endometrial/Uterine Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1667
p.A1478T	SIDM00173	Head and Neck Carcinoma	GDSC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.2778
p.A1478T	ACH-000618	Head and Neck Cancer	CCLE	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.2778
p.M1481V	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.1944
p.M1481V	ACH-000728	Leukemia	CCLE	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation rewiring degron network	0.1944
p.P1801S	SIDM01434	Hepatocellular Carcinoma	GDSC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.6752
p.P1801S	ACH-000316	Liver Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.6752
p.L1805I	ACH-000458	Skin Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.3056
p.T1472A	ACH-000786	Lymphoma	CCLE	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.825
p.T1472A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.825
p.R1788H	SNU-1040	large intestine	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation rewiring degron network	0.0833
p.V1392L	OC-314	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation altering degron motif	0.6765
p.G1404A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.0833
p.G1404A	DND-41	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.0833
p.G1404A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation rewiring degron network	0.0833
p.S1515L	KYSE-510	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation rewiring degron network	0.2222
p.T1804S	EN	endometrium	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.7116
p.T1476A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECTD1

UniProt ID: Q9ULT8

Entrez ID: 25831

Protein name: E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HECTD1 in