DegronMD - Q9ULT8(HECTD1)

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. {ECO:0000250|UniProtKB:Q69ZR2}.

GO - Biological processes (BP): anatomical structure development [GO:0048856]; aorta development [GO:0035904]; heart valve development [GO:0003170]; natural killer cell differentiation [GO:0001779]; negative regulation of protein localization to plasma membrane [GO:1903077]; neural tube closure [GO:0001843]; positive regulation of... View more >>

GO - Molecular function (MF): metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]

GO - Cellular component (CC):

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1511L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.S1511L	ACH-000824	Esophageal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.S1511L	KYSE-510	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	1507:1511	Mutation altering degron motif	0.8778
p.T1800A	TCGA-AA-3715	COAD	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.825
p.T1800A	DO8018	COAD	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.825
p.T1472A	ACH-000786	Lymphoma	CCLE	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.825
p.T1472A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.825
p.T1800S	SIDM01045	Endometrial Carcinoma	GDSC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.T1800S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.T1800S	EN	endometrium	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	1797:1804	Mutation altering degron motif	0.8227
p.T1472I	DO233871	GACA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.8189
p.P1348H	DO229029	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	1348:1352	Mutation altering degron motif	0.7694
p.S740L	DO228946	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7667
p.S1444C	DO50818	LIRI	ICGC	VGSSS	DEG_SPOP_SBC_1	1440:1444	Mutation altering degron motif	0.7541
p.S1529R	TCGA-IB-7651	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.7427
p.S1529R	DO46657	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	1527:1531	Mutation altering degron motif	0.7427
p.S1395R	DO229009	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1391:1395	Mutation altering degron motif	0.7427
p.S1380I	TCGA-AG-A002	READ	TCGA	AGSSS	DEG_SPOP_SBC_1	1376:1380	Mutation altering degron motif	0.7341
p.R1471C	TCGA-AN-A046	BRCA	TCGA	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719
p.R1471C	DO1285	BRCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	1470:1476	Mutation altering degron motif	0.719

Showing 1 to 20 of 174 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECTD1

UniProt ID: Q9ULT8

Entrez ID: 25831

Protein name: E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HECTD1 in