DegronMD

Uniprot ID: Q9ULT8

Source protein: E3 ubiquitin-protein ligase HECTD1

Source gene: HECTD1

Class: DEG_SPOP_SBC_1

Location: 1391:1395

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 76.96

COIL: 0.869

CONS_SCORE: 0.4061

DSS_SCORE: 0.3938

HELIX: 0.082

FCONS_SCORE: 1.0627

RIG_SCORE: 0.6652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1403N	TCGA-86-8673	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.2222
p.K1403N	DO26260	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.2222
p.S1398N	TCGA-A5-A0G2	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.25
p.S1398N	DO41235	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.G1400V	TCGA-BQ-7058	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400V	DO20788	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.S1385R	TCGA-GI-A2C8	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	0.6111
p.S1385R	DO5992	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.6111
p.T1404M	DO233634	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	0.0833
p.S1384R	DO228976	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.5833
p.S1384R	DO229032	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.5833
p.S1395R	DO229009	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.7427
p.G1400A	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	ACH-000786	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	ACH-000992	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	ACH-001067	Brain Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G1400A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1944
p.V1388L	SIDM00220	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.25
p.V1388L	ACH-000962	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.25
p.V1388L	ACH-001145	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.25
p.V1388L	OC-314	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	0.25
p.V1392L	OC-314	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	0.6765
p.G1404A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.0833
p.G1404A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.0833
p.G1404A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	290:294	VASSS	SPOP	0.9979	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	514:518	VASSS	SPOP	0.9614	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	351:355	VASSS	SPOP	0.9052	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	445:449	VASSS	SPOP	0.6862	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q5SVZ6	Zinc finger MYM-type protein 1	DEG_SPOP_SBC_1	395:399	VASSS	SPOP	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with HECTD1 mutations

All proteins holding degron of VASSS