DegronMD - Q5T5P2(KIAA1217)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1254Y	TCGA-85-6561	LUSC	TCGA	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0833
p.D1254Y	TCGA-BS-A0UF	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0833
p.D1254Y	DO26518	LUSC	ICGC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0833
p.D1254Y	DO41488	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0833
p.R1231I	TCGA-A5-A0G2	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.R1231I	TCGA-D1-A17Q	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.R1231I	DO41903	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.R1231I	DO41235	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.R165Q	TCGA-A6-6654	COAD	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165Q	TCGA-FI-A2D0	UCEC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165Q	DO9498	COAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165Q	DO43891	UCEC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.E1128K	TCGA-AG-A014	READ	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.0556
p.R165W	TCGA-AJ-A3BH	UCEC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165W	TCGA-G5-6572	READ	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165W	DO36696	READ	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.R165W	DO41638	UCEC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.D1417N	TCGA-AX-A05Z	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	TCGA-BS-A0UV	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	TCGA-E6-A1LX	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	TCGA-VQ-AA6A	STAD	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	DO222387	STAD	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	DO40884	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	DO41020	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.D1417N	DO42793	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1944
p.A1105V	TCGA-B5-A1MR	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.0833
p.D1069N	TCGA-B5-A3FC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation rewiring degron network	0.1667
p.S1119F	TCGA-BF-AAOX	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.3056
p.A168V	TCGA-BR-4184	STAD	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.5825
p.A168V	DO38328	STAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.5825
p.K1082N	TCGA-BR-A4CQ	STAD	TCGA	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation substituting flanking lysine	0.3611
p.P159L	TCGA-CW-6093	KIRC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.P159L	DO16248	KIRC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.S1118Y	TCGA-DA-A1IB	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation altering degron motif	0.712
p.V1414G	TCGA-DI-A2QY	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1111
p.V1414G	DO42031	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.1111
p.R167H	TCGA-DU-6400	LGG	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.8244
p.R167H	DO22109	LGG	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.8244
p.P1113S	TCGA-EB-A5FP	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.3056
p.T1915I	TCGA-EE-A29M	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.3056
p.T1915I	DO37404	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.3056
p.D1122N	TCGA-FR-A726	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.2222
p.E1127K	TCGA-FW-A3R5	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.0833
p.G1929R	TCGA-FW-A3R5	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.G1929R	TCGA-FW-A3TU	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.G1929R	DO37406	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.G1929R	DO37441	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.P1424S	TCGA-GF-A6C9	SKCM	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation altering degron motif	0.6752
p.P1424S	DO51254	SKCM	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation altering degron motif	0.6752
p.V1436M	TCGA-OR-A5K4	ACC	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.0833
p.V1436M	DO227587	COCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.0833
p.K1082E	TCGA-PG-A5BC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation substituting flanking lysine	0.3611
p.D1698N	TCGA-UY-A8OC	BLCA	TCGA	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation rewiring degron network	0.2778
p.D1698N	DO219038	BLCA	ICGC	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation rewiring degron network	0.2778
p.D1430N	TCGA-XF-AAN5	BLCA	TCGA	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.25
p.D1430N	DO51945	BLCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.25
p.E161K	DO494	BLCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.E161K	DO47584	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.V1700I	DO222463	BTCA	ICGC	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation altering degron motif	0.7076
p.D1430G	DO222427	BTCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation rewiring degron network	0.25
p.A160V	DO9876	COAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1667
p.S1699T	DO234307	ESAD	ICGC	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation rewiring degron network	0.3056
p.C1693F	DO229018	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation rewiring degron network	0.1389
p.C1693F	DO229036	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1700:1704	Mutation rewiring degron network	0.1389
p.V172L	DO229045	LICA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.5654
p.N1928S	DO23486	LINC	ICGC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1667
p.D178N	DO222363	MELA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.2222
p.E181K	DO222599	MELA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.E181K	DO218863	SKCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.A156V	DO232761	PBCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.0556
p.S161Y	DO228397	PRAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.K172Q	DO37531	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.6944
p.M164I	DO37738	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.2778
p.P177S	DO37798	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.25
p.K172I	DO51269	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.7531
p.T1109N	SIDM00684	Glioblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation blocking phosphorylation signal	0.6389
p.T1109N	LN-229	central nervous system	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation blocking phosphorylation signal	0.6389
p.T1922A	SIDM00845	Burkitt's Lymphoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation altering degron motif	0.7139
p.S164R	SIDM00336	Melanoma	GDSC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.2778
p.G1912S	SIDM00427	Ewing's Sarcoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.2222
p.G1912S	RH-1	soft tissue	COSMIC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.2222
p.G1909C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.G1909C	ACH-002256	Leukemia	CCLE	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.G1909C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation rewiring degron network	0.1389
p.S161P	SIDM00457	Plasma Cell Myeloma	GDSC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.S161P	ACH-000024	Myeloma	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.S161P	OPM-2	haematopoietic and lymphoid tissue	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1944
p.G1074S	SIDM00819	Kidney Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation rewiring degron network	0.3056
p.E1238K	SIDM00299	Other Sarcomas	GDSC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.25
p.E1238K	ACH-002271	Sarcoma	CCLE	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.25
p.E1238K	MFH-ino	soft tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.25
p.T1423A	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation altering degron motif	0.7139
p.H1917N	SIDM01608	Endometrial Carcinoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	1916:1922	Mutation altering degron motif	0.6312
p.G1089R	SIDM00011	Melanoma	GDSC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation rewiring degron network	0.0556
p.E1243D	SIDM01588	Endometrial Carcinoma	GDSC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation altering degron motif	0.6758
p.E1243D	ACH-000993	Endometrial/Uterine Cancer	CCLE	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation altering degron motif	0.6758
p.Q1426K	ACH-000117	Breast Cancer	CCLE	MTPRQE	DEG_SCF_FBW7_2	1422:1427	Mutation altering degron motif	0.5833
p.P177R	ACH-002275	Leukemia	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.25
p.P177R	MN-60	haematopoietic and lymphoid tissue	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.25
p.R182K	ACH-002396	Bone Cancer	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1111
p.R182K	Sarc9371	bone	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1111
p.P1113L	FADU	upper aerodigestive tract	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.3056
p.L1236F	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation substituting flanking lysine	0.3056
p.L1126F	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.1111
p.D1125Y	NCI-H1568	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.1389
p.D1252Y	EB-3	haematopoietic and lymphoid tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.1389
p.S1240L	ME-180	cervix	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.3056
p.E1066K	SW900	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation rewiring degron network	0.0833
p.T1074N	LN-229	central nervous system	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation rewiring degron network	0.3056
p.P1077L	FADU	upper aerodigestive tract	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation altering degron motif	0.7582
p.K1076N	CW-2	large intestine	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation altering degron motif	0.6918
p.S1115L	COLO-792	skin	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation altering degron motif	0.7667
p.P1232L	Mewo	skin	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0833
p.D1124Y	NCI-H1568	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.1667
p.G1233S	RH-1	soft tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.1111
p.R1123Q	TT	thyroid	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.1944
p.P1078L	FADU	upper aerodigestive tract	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation altering degron motif	0.7582
p.E1067K	SW900	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation blocking phosphorylation signal	0.5556
p.A1255S	TMK-1	stomach	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.A1255S	HuO9	bone	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation rewiring degron network	0.0556
p.S1237L	HT-115	large intestine	COSMIC	MKENS	DEG_APCC_KENBOX_2	1241:1245	Mutation blocking phosphorylation signal	0.6667
p.T1073N	LN-229	central nervous system	COSMIC	RKENI	DEG_APCC_KENBOX_2	1075:1079	Mutation blocking phosphorylation signal	0.7222
p.S1114L	COLO-792	skin	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation altering degron motif	0.7667
p.R1122Q	TT	thyroid	COSMIC	PVTTS	DEG_SPOP_SBC_1	1114:1118	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1217

UniProt ID: Q5T5P2

Entrez ID: 56243

Protein name: Sickle tail protein homolog

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KIAA1217 in