DegronMD

Uniprot ID: Q5T5P2

Source protein: Sickle tail protein homolog

Source gene: KIAA1217

Class: DEG_APCC_DBOX_1

Location: 166:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.991

ASA_SCORE: 81.8556

COIL: 0.7673

CONS_SCORE: 0.7818

DSS_SCORE: 0.582

HELIX: 0.0392

FCONS_SCORE: 1.2264

RIG_SCORE: 0.7078

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R165Q	TCGA-A6-6654	COAD	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165Q	TCGA-FI-A2D0	UCEC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165Q	DO9498	COAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165Q	DO43891	UCEC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165W	TCGA-AJ-A3BH	UCEC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165W	TCGA-G5-6572	READ	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165W	DO36696	READ	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.R165W	DO41638	UCEC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.3056
p.A168V	TCGA-BR-4184	STAD	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.5825
p.A168V	DO38328	STAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.5825
p.P159L	TCGA-CW-6093	KIRC	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.1389
p.P159L	DO16248	KIRC	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1389
p.R167H	TCGA-DU-6400	LGG	TCGA	TRASLPVVR	DEG_APCC_DBOX_1	0.8244
p.R167H	DO22109	LGG	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.8244
p.E161K	DO494	BLCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.E161K	DO47584	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.A160V	DO9876	COAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1667
p.V172L	DO229045	LICA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.5654
p.D178N	DO222363	MELA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.2222
p.E181K	DO222599	MELA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1389
p.E181K	DO218863	SKCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1389
p.A156V	DO232761	PBCA	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.0556
p.S161Y	DO228397	PRAD	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.K172Q	DO37531	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.6944
p.M164I	DO37738	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.2778
p.P177S	DO37798	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.25
p.K172I	DO51269	SKCM	ICGC	TRASLPVVR	DEG_APCC_DBOX_1	0.7531
p.S164R	SIDM00336	Melanoma	GDSC	TRASLPVVR	DEG_APCC_DBOX_1	0.2778
p.S161P	SIDM00457	Plasma Cell Myeloma	GDSC	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.S161P	ACH-000024	Myeloma	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.S161P	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	0.1944
p.P177R	ACH-002275	Leukemia	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	0.25
p.P177R	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	0.25
p.R182K	ACH-002396	Bone Cancer	CCLE	TRASLPVVR	DEG_APCC_DBOX_1	0.1111
p.R182K	Sarc9371	bone	COSMIC	TRASLPVVR	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRASLPVVR

Degron related mutations and impact score

Drug responses associated with KIAA1217 mutations

All proteins holding degron of TRASLPVVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5P2	Sickle tail protein homolog	DEG_APCC_DBOX_1	166:174	TRASLPVVR	APC,CDC20,FZR1	0.991	More...